The MARINA Risk Assessment Strategy: A Flexible Strategy for Efficient Information Collection and Risk Assessment of Nanomaterials

Peter M. J. Bos, Stefania Gottardo, Janeck J. Scott-Fordsmand, Martie Van Tongeren, Elena Semenzin, Teresa F. Fernandes, Danail Hristozov, Kerstin Hund-Rinke, Neil Hunt, Muhammad-Adeel Irfan, Robert Landsiedel, Willie J. G. M. Peijnenburg, Araceli Sánchez Jiménez, Petra C. E. Van Kesteren and Agnes G. Oomen
Additional contact information
Peter M. J. Bos: National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720 BA, The Netherlands
Stefania Gottardo: European Commission, Joint Research Centre, Via E. Fermi 2749, Ispra (VA) 21027, Italy
Janeck J. Scott-Fordsmand: Department of Bioscience, Aarhus University, Vejlsøvej 25, PO Box 314, Silkeborg 8600, Denmark
Martie Van Tongeren: Institute of Occupational Medicine, Centre for Human Exposure Science (CHES), Research Avenue North, Riccarton, Edinburgh EH14 4AP, UK
Elena Semenzin: Department of Environmental Sciences, Informatics and Statistics, University Ca’ Foscari of Venice, c/o VEGApark, Via delle Industrie 21/8, Marghera (VE) 30175, Italy
Teresa F. Fernandes: School of Life Sciences, Heriot-Watt University, Edinburgh EH14 4AS, UK
Danail Hristozov: Department of Environmental Sciences, Informatics and Statistics, University Ca’ Foscari of Venice, c/o VEGApark, Via delle Industrie 21/8, Marghera (VE) 30175, Italy
Kerstin Hund-Rinke: Fraunhofer Institute for Molecular Biology and Applied Ecology, Auf dem Aberg 1, Schmallenberg 57392, Germany
Neil Hunt: The REACH Centre, Gordon Manley Building, Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, UK
Muhammad-Adeel Irfan: Experimental Toxicology and Ecology, BASF SE, GB/TB-Z470, Ludwigshafen 67056, Germany
Robert Landsiedel: Experimental Toxicology and Ecology, BASF SE, GB/TB-Z470, Ludwigshafen 67056, Germany
Willie J. G. M. Peijnenburg: National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720 BA, The Netherlands
Araceli Sánchez Jiménez: Institute of Occupational Medicine, Centre for Human Exposure Science (CHES), Research Avenue North, Riccarton, Edinburgh EH14 4AP, UK
Petra C. E. Van Kesteren: National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720 BA, The Netherlands
Agnes G. Oomen: National Institute for Public Health and the Environment (RIVM), PO Box 1, Bilthoven 3720 BA, The Netherlands

IJERPH, 2015, vol. 12, issue 12, 1-15

Abstract: An engineered nanomaterial (ENM) may actually consist of a population of primary particles, aggregates and agglomerates of various sizes. Furthermore, their physico-chemical characteristics may change during the various life-cycle stages. It will probably not be feasible to test all varieties of all ENMs for possible health and environmental risks. There is therefore a need to further develop the approaches for risk assessment of ENMs. Within the EU FP7 project Managing Risks of Nanoparticles (MARINA) a two-phase risk assessment strategy has been developed. In Phase 1 (Problem framing) a base set of information is considered, relevant exposure scenarios (RESs) are identified and the scope for Phase 2 (Risk assessment) is established. The relevance of an RES is indicated by information on exposure, fate/kinetics and/or hazard; these three domains are included as separate pillars that contain specific tools. Phase 2 consists of an iterative process of risk characterization, identification of data needs and integrated collection and evaluation of data on the three domains, until sufficient information is obtained to conclude on possible risks in a RES. Only data are generated that are considered to be needed for the purpose of risk assessment. A fourth pillar, risk characterization, is defined and it contains risk assessment tools. This strategy describes a flexible and efficient approach for data collection and risk assessment which is essential to ensure safety of ENMs. Further developments are needed to provide guidance and make the MARINA Risk Assessment Strategy operational. Case studies will be needed to refine the strategy.

Keywords: nanomaterials; risk assessment strategy; exposure-driven; problem framing (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (3)

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