Sex-Dependent Depression-Like Behavior Induced by Respiratory Administration of Aluminum Oxide Nanoparticles

Xin Zhang, Yan Xu, Lian Zhou, Chengcheng Zhang, Qingtao Meng, Shenshen Wu, Shizhi Wang, Zhen Ding, Xiaodong Chen, Xiaobo Li and Rui Chen
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Xin Zhang: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
Yan Xu: Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China
Lian Zhou: Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China
Chengcheng Zhang: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
Qingtao Meng: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
Shenshen Wu: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
Shizhi Wang: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
Zhen Ding: Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China
Xiaodong Chen: Department of Environmental Health and Endemic Disease Control, Jiangsu Provincial, Center for Disease Prevention and Control, Nanjing 210009, China
Xiaobo Li: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China
Rui Chen: Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing 210009, China

IJERPH, 2015, vol. 12, issue 12, 1-14

Abstract: Ultrafine aluminum oxide, which are abundant in ambient and involved occupational environments, are associated with neurobehavioral alterations. However, few studies have focused on the effect of sex differences following exposure to environmental Al 2 O 3 ultrafine particles. In the present study, male and female mice were exposed to Al 2 O 3 nanoparticles (NPs) through a respiratory route. Only the female mice showed depression-like behavior. Although no obvious pathological changes were observed in mice brain tissues, the neurotransmitter and voltage-gated ion channel related gene expression, as well as the small molecule metabolites in the cerebral cortex, were differentially modulated between male and female mice. Both mental disorder-involved gene expression levels and metabolomics analysis results strongly suggested that glutamate pathways were implicated in sex differentiation induced by Al 2 O 3 NPs. Results demonstrated the potential mechanism of environmental ultrafine particle-induced depression-like behavior and the importance of sex dimorphism in the toxic research of environmental chemicals.

Keywords: depressive; nanoparticles; glutamate; aluminum oxide; sex difference (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
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