Indoor and Outdoor Exposure to Ultrafine, Fine and Microbiologically Derived Particulate Matter Related to Cardiovascular and Respiratory Effects in a Panel of Elderly Urban Citizens

Dorina Gabriela Karottki, Michal Spilak, Marie Frederiksen, Zorana Jovanovic Andersen, Anne Mette Madsen, Matthias Ketzel, Andreas Massling, Lars Gunnarsen, Peter Møller and Steffen Loft
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Dorina Gabriela Karottki: Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, DK-1014, Copenhagen, Denmark
Michal Spilak: Danish Building Research Institute, Department of Construction and Health, Aalborg University, Copenhagen, Denmark
Marie Frederiksen: Danish Building Research Institute, Department of Construction and Health, Aalborg University, Copenhagen, Denmark
Zorana Jovanovic Andersen: Center for Epidemiology and Screening, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, DK-1014 Copenhagen, Denmark
Anne Mette Madsen: National Research Centre for the Working Environment, Lersø Parkallé 105, 2100 Copenhagen, Denmark
Matthias Ketzel: Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark
Andreas Massling: Department of Environmental Science, Aarhus University, Frederiksborgvej 399, 4000 Roskilde, Denmark
Lars Gunnarsen: Danish Building Research Institute, Department of Construction and Health, Aalborg University, Copenhagen, Denmark
Peter Møller: Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, DK-1014, Copenhagen, Denmark
Steffen Loft: Section of Environmental Health, Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Øster Farimagsgade 5, DK-1014, Copenhagen, Denmark

IJERPH, 2015, vol. 12, issue 2, 1-20

Abstract: To explore associations of exposure to ambient and indoor air particulate and bio-aerosol pollutants with cardiovascular and respiratory disease markers, we utilized seven repeated measurements from 48 elderly subjects participating in a 4-week home air filtration study. Microvascular function (MVF), lung function, blood leukocyte counts, monocyte adhesion molecule expression, C-reactive protein, Clara cell protein (CC16) and surfactant protein-D (SPD) were examined in relation to exposure preceding each measurement. Exposure assessment included 48-h urban background monitoring of PM 10 , PM 2.5 and particle number concentration (PNC), weekly measurements of PM 2.5 in living- and bedroom, 24-h measurements of indoor PNC three times, and bio-aerosol components in settled dust on a 2-week basis. Statistically significant inverse associations included: MVF with outdoor PNC; granulocyte counts with PM 2.5 ; CD31 expression with dust fungi; SPD with dust endotoxin. Significant positive associations included: MVF with dust bacteria; monocyte expression of CD11 with PM 2.5 in the bedroom and dust bacteria and endotoxin, CD31 expression with dust serine protease; serum CC16 with dust NAGase. Multiple comparisons demand cautious interpretation of results, which suggest that outdoor PNC have adverse effects on MVF, and outdoor and indoor PM 2.5 and bio-aerosols are associated with markers of inflammation and lung cell integrity.

Keywords: ultrafine particles; indoor air pollution; ambient air pollution; PM 2.5; bioaerosols; microvascular function; lung function; inflammation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (7)

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