Impact of Air Pollutants on Oxidative Stress in Common Autophagy-Mediated Aging Diseases

Mohamed Saber Numan, Jacques P. Brown and Laëtitia Michou
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Mohamed Saber Numan: Department of Endocrinology and Nephrology, Centre Hospitalier Universitaire de Québec Research Centre, Québec, QC, G1V 4G2, Canada
Jacques P. Brown: Department of Endocrinology and Nephrology, Centre Hospitalier Universitaire de Québec Research Centre, Québec, QC, G1V 4G2, Canada
Laëtitia Michou: Department of Endocrinology and Nephrology, Centre Hospitalier Universitaire de Québec Research Centre, Québec, QC, G1V 4G2, Canada

IJERPH, 2015, vol. 12, issue 2, 1-17

Abstract: Atmospheric pollution-induced cellular oxidative stress is probably one of the pathogenic mechanisms involved in most of the common autophagy-mediated aging diseases, including neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer’s, disease, as well as Paget’s disease of bone with or without frontotemporal dementia and inclusion body myopathy. Oxidative stress has serious damaging effects on the cellular contents: DNA, RNA, cellular proteins, and cellular organelles. Autophagy has a pivotal role in recycling these damaged non-functional organelles and misfolded or unfolded proteins. In this paper, we highlight, through a narrative review of the literature, that when autophagy processes are impaired during aging, in presence of cumulative air pollution-induced cellular oxidative stress and due to a direct effect on air pollutant, autophagy-mediated aging diseases may occur.

Keywords: Paget’s disease of bone; neurodegenerative diseases; autophagy; SQSTM1/p62; oxidative stress; cigarettes; tobacco smoke; wood heating; air pollutants; aging (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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