Rationally Modified Estrogen Receptor Protein as a Bio-Recognition Element for the Detection of EDC Pollutants: Strategies and Opportunities

Mattia Pedotti, Valentina Elisabetta Viviana Ferrero, Teresa Lettieri, Pascal Colpo, Stephane Follonier, Luigi Calzolai and Luca Varani
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Mattia Pedotti: Institute for Research in Biomedicine, Universita' della Svizzera italiana (USI) via Vela 6, 6500 Bellinzona, Switzerland
Valentina Elisabetta Viviana Ferrero: European Commission—Directorate General—Joint Research Centre, Institute for Environment and Sustainability, Ispra, Varese 21027, Italy
Teresa Lettieri: European Commission—Directorate General—Joint Research Centre, Institute for Environment and Sustainability, Ispra, Varese 21027, Italy
Pascal Colpo: European Commission–Directorate General–Joint Research Centre, Institute for Health and Consumer Protection, Ispra, Varese 21027, Italy
Stephane Follonier: CSEM Landquart, Bahnhofstrasse 1, Landquart 7302, Switzerland
Luigi Calzolai: European Commission–Directorate General–Joint Research Centre, Institute for Health and Consumer Protection, Ispra, Varese 21027, Italy
Luca Varani: Institute for Research in Biomedicine, Universita' della Svizzera italiana (USI) via Vela 6, 6500 Bellinzona, Switzerland

IJERPH, 2015, vol. 12, issue 3, 1-10

Abstract: The estrogen receptor protein (ER) can bind a vast number of organic pollutants widely spread in the environment and collectively known as Endocrine Disrupting Chemicals, EDCs. Its broad selectivity makes it an ideal bio-recognition element for the detection of EDCs. Here we describe the strategy and rationale for the design of ER based biosensors and assays that generate a signal in the presence of EDCs. The opportunity to use either natural or rationally modified ER molecules is discussed. The latter approach was successfully applied in the EU-FP7 project RADAR, with the aim to develop a novel biosensor for the detection of organic pollutants both in the environment and in commercial water products.

Keywords: estrogen receptor; EDC; biosensor; pollutants (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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