Correlation of Zinc with Oxidative Stress Biomarkers

María Morales-Suárez-Varela, Agustín Llopis-González, Verónica González-Albert, Raúl López-Izquierdo, Isabel González-Manzano, Javier Cháves, Vicente Huerta-Biosca and Juan C. Martin-Escudero
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María Morales-Suárez-Varela: Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain
Agustín Llopis-González: Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain
Verónica González-Albert: Genotyping and Genetic Diagnosis Unit Hospital Clinic Research Foundation and INCLIVA, University of Valencia, 46010 Valencia, Spain
Raúl López-Izquierdo: Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain
Isabel González-Manzano: Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain
Javier Cháves: Genotyping and Genetic Diagnosis Unit Hospital Clinic Research Foundation and INCLIVA, University of Valencia, 46010 Valencia, Spain
Vicente Huerta-Biosca: Unit of Public Health, Hygiene and Environmental Health, Department of Preventive Medicine and Public Health, Food Science, Toxicology and Legal Medicine, University of Valencia, 46100 Valencia, Spain
Juan C. Martin-Escudero: Internal Medicine Department, Rio Hortega University Hospital, 47012 Valladolid, Spain

IJERPH, 2015, vol. 12, issue 3, 1-17

Abstract: Hypertension and smoking are related with oxidative stress (OS), which in turn reports on cellular aging. Zinc is an essential element involved in an individual’s physiology. The aim of this study was to evaluate the relation of zinc levels in serum and urine with OS and cellular aging and its effect on the development of hypertension. In a Spanish sample with 1500 individuals, subjects aged 20–59 years were selected, whose zinc intake levels fell within the recommended limits. These individuals were classified according to their smoking habits and hypertensive condition. A positive correlation was found (Pearson’s C = 0.639; p = 0.01) between Zn serum/urine quotient and oxidized glutathione levels (GSSG). Finally, risk of hypertension significantly increased when the GSSG levels exceeded the 75 percentile; OR = 2.80 (95%CI = 1.09–7.18) and AOR = 3.06 (95%CI = 0.96–9.71). Low zinc levels in serum were related with OS and cellular aging and were, in turn, to be a risk factor for hypertension.

Keywords: zinc; oxidative stress; hypertension; cellular aging (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
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