Monoamine Oxidase A Promoter Variable Number of Tandem Repeats ( MAOA-uVNTR ) in Alcoholics According to Lesch Typology

Agnieszka Samochowiec, Magdalena Chęć, Edyta Kopaczewska, Jerzy Samochowiec, Otto Lesch, Elżbieta Grochans, Andrzej Jasiewicz, Przemyslaw Bienkowski, Łukasz Kołodziej and Anna Grzywacz
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Agnieszka Samochowiec: Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Krakowska 69, 71-017 Szczecin, Poland
Magdalena Chęć: Institute of Psychology, Department of Clinical Psychology, University of Szczecin, Krakowska 69, 71-017 Szczecin, Poland
Edyta Kopaczewska: University Center for Education, University of Szczecin, Szwoleżerów 18a, 71-062 Szczecin, Poland
Jerzy Samochowiec: Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland
Otto Lesch: Department of Psychiatry, Vienna University, Waehringer Guertel 18–20, A-1090 Vienna, Austria
Elżbieta Grochans: Department of Nursing, Pomeranian Medical University, Żołnierska 48, 71-210 Szczecin, Poland
Andrzej Jasiewicz: Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland
Przemyslaw Bienkowski: Institute of Psychiatry and Neurology, Department of Pharmacology, Sobieskiego 9, 02-957 Warszawa, Poland
Łukasz Kołodziej: Department of Orthopedics, Pomeranian Medical University, Unii Lubelskiej 1, 71-460 Szczecin, Poland
Anna Grzywacz: Department of Psychiatry, Pomeranian Medical University, Broniewskiego 26, 71-460 Szczecin, Poland

IJERPH, 2015, vol. 12, issue 3, 1-10

Abstract: Background: The aim of this study was to examine the association between the MAOA-uVNTR gene polymorphism in a homogeneous subgroups of patients with alcohol dependence categorized according to Lesch’s typology. Methods: DNA was provided from alcohol dependent (AD) patients (n = 370) and healthy control subjects (n = 168) all of Polish descent. The history of alcoholism was obtained using the Polish version of the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA). Samples were genotyped using PCR methods. Results: We found no association between alcohol dependence and MAOA gene polymorphism. Conclusions: Lesch typology is a clinical consequence of the disease and its phenotypic description is too complex for a simple genetic analysis.

Keywords: alcohol dependence; MAOA; Lesch’s typology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
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