An Analysis of the Influence of Selected Genetic and Hormonal Factors on the Occurrence of Depressive Symptoms in Late-Reproductive-Age Women

Anna Jurczak, Małgorzata Szkup, Agnieszka Samochowiec, Anna Grzywacz, Jerzy Samochowiec, Beata Karakiewicz, Barbara Dołęgowska and Elżbieta Grochans
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Anna Jurczak: Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland
Małgorzata Szkup: Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland
Agnieszka Samochowiec: Department of Clinical Psychology, Institute of Psychology, University of Szczecin, ul. Krakowska 71–79, 71-017 Szczecin, Poland
Anna Grzywacz: Department of Psychiatry, Pomeranian Medical University in Szczecin, Broniewskiego Str. 26, 71-460 Szczecin, Poland
Jerzy Samochowiec: Department of Psychiatry, Pomeranian Medical University in Szczecin, Broniewskiego Str. 26, 71-460 Szczecin, Poland
Beata Karakiewicz: Public Health Department, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland
Barbara Dołęgowska: Laboratory of Stem Cell Physiology and Biochemistry, Division and Department of Physiology, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland
Elżbieta Grochans: Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland

IJERPH, 2015, vol. 12, issue 4, 1-17

Abstract: Background : The aim of this study was to analyze the influence of genetic and hormonal factors on incidences of depressive symptoms in late-reproductive-age women. Methods : The study was performed using the Beck Depression Inventory, the PCR, and genetic tests of 347 healthy late-reproductive-age Polish women. Results : The relationship between the level of anti- Müllerian hormone (AMH) and depressive symptoms was not statistically significant ( p > 0.05). Increases in age and FSH levels were accompanied by a decrease in AMH level in a significant way ( p < 0.05). There were no statistically significant relationships between the distribution of genotypes and the frequency of alleles of the investigated polymorphisms and depressive symptoms according to the Beck Depression Inventory. Conclusions : (1) The presence of the s/s genotype of the 5-HTTLPR polymorphism in the serotonin transporter promoter region and the 3/3 genotype of the 30-bp VNTR polymorphism in the monoamine oxidase A promoter region does not contribute to the development of depressive symptoms in late-reproductive-age women. (2) A relationship between the level of anti- Müllerian hormone and depressive symptoms was not confirmed in the group of healthy late-reproductive-age women. (3) AMH level correlates negatively with FSH level and age, which confirms that AMH can be regarded as a factor reflecting the ovarian reserve.

Keywords: polymorphism; AMH; FSH; late reproductive period; depressive symptoms; 5-HTTLPR; MAO-A (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
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