Ninety Day Toxicity and Toxicokinetics of Fluorochloridone after Oral Administration in Rats

Suhui Zhang, Xiaoqin Cheng, Yu Wang, Junpei Fan, Rui Li, Su Zhou, Shihong Liu, Jingmin Shi, Jie Sun, Yue Hu, Chaojin Xu, Chunhua Wu, Xiuli Chang, Liming Tang and Zhijun Zhou
Additional contact information
Suhui Zhang: School of Public Health, Fudan University, Shanghai 200032, China
Xiaoqin Cheng: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Yu Wang: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Junpei Fan: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Rui Li: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Su Zhou: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Shihong Liu: School of Public Health, Fudan University, Shanghai 200032, China
Jingmin Shi: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Jie Sun: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Yue Hu: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Chaojin Xu: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Chunhua Wu: School of Public Health, Fudan University, Shanghai 200032, China
Xiuli Chang: School of Public Health, Fudan University, Shanghai 200032, China
Liming Tang: Pharmacology and Toxicology Department, Shanghai Institute for Food and Drug Control, Shanghai 201203, China
Zhijun Zhou: School of Public Health, Fudan University, Shanghai 200032, China

IJERPH, 2015, vol. 12, issue 5, 1-25

Abstract: The ninety day toxicity and toxicokinetics of fluorochloridone (FLC) were accessed in Wistar rats. Animals were gavaged with FLC at doses of 31.25 mg/kg, 125 mg/kg and 500 mg/kg for ninety days, followed by thirty days for recovery. On the 1st, 60th, 75th and 90th days of the dosing phase, plasma of ten animals of all groups treated with FLC was collected for toxicokinetic analysis of FLC by an UPLC-MS/MS method. Numerous changes in body weight, hematology, serum chemistry, and organ weight ratios were observed by the 45th and 90th dosing day. Most changes in groups treated with FLC were absent on the last recovery day. Testis and epididymis lesions were consistently seen in histopathological observations on the 45th, 90th dosing day and the last recovery day. Repeated administration of FLC increased the level of testosterone in serum in male rats on the 90th dosing day. FLC plasma concentrations could be detected in all animal drug-treated groups during the dosing phase, and a dose proportional relationship was seen between FLC dose and AUC or C max . This study will support future studies on the mechanism of FLC-induced toxicity.

Keywords: fluorochloridone; ninety days toxicity; gavage; toxicokinetics; UPLC-MS/MS; rat (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (3)

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