Association of Serum Free Fatty Acids with Hypertension and Insulin Resistance among Rural Uyghur Adults in Far Western China

Shu-Xia Guo, Yi-Zhong Yan, La-Ti Mu, Qiang Niu, Jia He, Jia-Ming Liu, Shu-Gang Li, Jing-Yu Zhang, Heng Guo and Dong-Sheng Rui
Additional contact information
Shu-Xia Guo: Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China
Yi-Zhong Yan: Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China
La-Ti Mu: Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China
Qiang Niu: Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China
Jia He: Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China
Jia-Ming Liu: Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China
Shu-Gang Li: Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China
Jing-Yu Zhang: Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China
Heng Guo: Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China
Dong-Sheng Rui: Department of Public Health, Shihezi University School of Medicine, Shihezi, Xinjiang 832000, China

IJERPH, 2015, vol. 12, issue 6, 1-9

Abstract: Objective : We aimed to investigate whether free fatty acid (FFA) levels in hypertensive patients result from increased blood pressure or the accompanying condition of insulin resistance (IR). Furthermore, we aimed to study the role of IR in the onset and development of hypertension and then provide a basis for the prevention and treatment of hypertension and metabolic syndrome (MS). Design and Methods : The study included 68 essential hypertensive patients without IR, 87 normotensive subjects with IR, 82 essential hypertensive patients with IR and 74 normotensive subjects without IR. Analysis of covariance was used to compare FFA concentrations among the four groups to determine the association between FFA concentrations and hypertension and IR. Results : A significant difference in FFA concentrations among the four groups was found using a one-factor analysis of variance ( p < 0.001). A significant difference was also found among the adjusted means of the four groups (essential hypertensive patients with IR vs. normotensive subjects without IR: 0.703 mg/L vs. 0.516 mg/L, p < 0.001; essential hypertensive patients with IR vs. normotensive subjects with IR: 0.703 mg/L vs. 0.525 mg/L, p < 0.001; essential hypertensive patients with IR vs. essential hypertensive patients without IR: 0.703 mg/L vs. 0.579 mg/L, p = 0.002; normotensive subjects with IR vs. normotensive subjects without IR: 0.525 mg/L vs. 0.516 mg/L, p = 0.007; essential hypertensive patients without IR vs. normotensive subjects without IR: 0.579 mg/L vs. 0.516 mg/L, p < 0.001). However, no significant interaction was detected between IR and hypertension regarding the FFA concentration. Conclusions : FFA is an independent factor for IR and hypertension among Uyghur adults in a rural area of Xinjiang.

Keywords: Uyghur; hypertension; IR; FFA (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/12/6/6582/pdf (application/pdf)
https://www.mdpi.com/1660-4601/12/6/6582/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:12:y:2015:i:6:p:6582-6590:d:50917

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().