Incidence Density and Risk Factors of Diabetic Retinopathy Within Type 2 Diabetes: A Five-Year Cohort Study in China (Report 1)

Lei Liu, Jingyang Wu, Song Yue, Jin Geng, Jie Lian, Weiping Teng, Desheng Huang and Lei Chen
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Lei Liu: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China
Jingyang Wu: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China
Song Yue: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China
Jin Geng: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China
Jie Lian: Department of Healthcenter, Fengyutan Community, Shenyang, 110014, China
Weiping Teng: Key Laboratory of Endocrine Diseases in Liaoning Province, The First Hospital of China Medical University, Shenyang, 110001, China
Desheng Huang: Department of Epidemiology, School of Public Health, China Medical University, Shenyang, 110122, China
Lei Chen: Department of Ophthalmology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China

IJERPH, 2015, vol. 12, issue 7, 1-11

Abstract: A prospective study was carried out from August 2010 to August 2014 in the community of Fengyutan (China). Six hundred and twenty two T2D subjects were collected. The incidence density of diabetic retinopathy (DR) was 1.81% person-year (95% confidence interval, CI: 1.21–2.43% person-year). After a Cox regression model analysis and adjusted confounding factors, independent predictors related to the incidence of DR including male gender (adjusted hazard ratios, aHR: 1.47, 95% CI: 1.21–1.62), with hypertension (aHR: 1.49, 95%: 1.12–1.73), duration of diabetes > 10 years (aHR: 2.28, 95%: 2.05–2.42), uncontrolled diabetes (aHR: 1.76, 95%: 1.41–2.01), total cholesterol ? 200 mg/dL (aHR: 1.54, 95%: 1.34–1.72) and HbA1c ? 7% (mmol/mol) (aHR: 2.12, 95%: 1.87–2.32). Duration of T2D revealed the significantly dose-response relationship to the onset of DR. The incidence density of DR in the Chinese community was relatively low in comparison with other studies. More attention should be paid to the T2D patients, especially of male gender, with hypertension, longer duration of diabetes, uncontrolled diabetes, total cholesterol ? 200mg/dL and HbA1c ? 7% (mmol/mol).

Keywords: community; diabetic retinopathy; epidemiology; incidence density; risk factors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
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