The Effects of Lead Exposure on Serum Uric Acid and Hyperuricemia in Chinese Adults: A Cross-Sectional Study

Haijiang Dai, Zhijun Huang, Qihong Deng, Ying Li, Ting Xiao, Xingping Ning, Yao Lu and Hong Yuan
Additional contact information
Haijiang Dai: The Third Xiangya Hospital, Central South University, Changsha 410013, China
Zhijun Huang: The Third Xiangya Hospital, Central South University, Changsha 410013, China
Qihong Deng: Institute of Environment and Health, Central South University, Changsha 410013, China
Ying Li: The Third Xiangya Hospital, Central South University, Changsha 410013, China
Ting Xiao: The Third Xiangya Hospital, Central South University, Changsha 410013, China
Xingping Ning: Centers for Disease Control and Prevention, Zixing 423400, China
Yao Lu: The Third Xiangya Hospital, Central South University, Changsha 410013, China
Hong Yuan: The Third Xiangya Hospital, Central South University, Changsha 410013, China

IJERPH, 2015, vol. 12, issue 8, 1-11

Abstract: The aim of this study was to assess the correlation between blood lead levels and both serum uric acid and hyperuricemia in adult residents living within an area of China with lead pollution. We conducted a cross-sectional analysis of 2120 subjects (1180 of whom were male) between the ages of 20 and 75 years who had undergone health examinations at the Centers for Disease Control and Prevention (CDC) in a lead-polluted area of China between June 2013 and September 2014. Blood lead was positively correlated with serum uric acid in both males (r = 0.095, p = 0.001) and females (r = 0.134, p < 0.001). Multivariate linear regression analysis demonstrated that for males, blood lead ( p = 0.006), age ( p = 0.001), current smoking ( p = 0.012), education ( p = 0.001), triglycerides (TG) ( p < 0.001), and serum creatinine ( p < 0.001) were independently associated with serum uric acid. For females, blood lead ( p < 0.001), body mass index (BMI) ( p = 0.009), and TG ( p < 0.001) were independently associated with serum uric acid. After multiple adjustments, blood lead was significantly associated with a higher prevalence of hyperuricemia when female subjects were categorized into quartiles (for the highest quartile vs. the lowest quartile, odds ratio (OR) = 2.190; 95% confidence interval (CI): 1.106–4.338; p = 0.025); however, no such association was observed for male subjects. Continuous lead exposure has an independent impact on serum uric acid for both males and females, although this impact is more pronounced for females than for males. Lead exposure is significantly associated with hyperuricemia for females but not for males.

Keywords: lead exposure; uric acid; hyperuricemia; non-occupational exposure (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

Downloads: (external link)
https://www.mdpi.com/1660-4601/12/8/9672/pdf (application/pdf)
https://www.mdpi.com/1660-4601/12/8/9672/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:12:y:2015:i:8:p:9672-9682:d:54328

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().