Thyroid Autoimmunity is Associated with Decreased Cytotoxicity T Cells in Women with Repeated Implantation Failure

Chunyu Huang, Peiyan Liang, Lianghui Diao, Cuicui Liu, Xian Chen, Guangui Li, Cong Chen and Yong Zeng
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Chunyu Huang: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China
Peiyan Liang: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China
Lianghui Diao: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China
Cuicui Liu: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China
Xian Chen: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China
Guangui Li: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China
Cong Chen: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China
Yong Zeng: Fertility Center, Shenzhen Zhongshan Urology Hospital, Shenzhen 518045, China

IJERPH, 2015, vol. 12, issue 9, 1-10

Abstract: Thyroid autoimmunity (TAI), which is defined as the presence of autoantibodies against thyroid peroxidase (TPO) and/or thyroglobulin (TG), is related to repeated implantation failure (RIF). It is reported that TAI was involved in reproductive failure not only through leading thyroid function abnormality, but it can also be accompanied with immune imbalance. Therefore, this study was designed to investigate the association of thyroid function, immune status and TAI in women with RIF. Blood samples were drawn from 72 women with RIF to evaluate the prevalence of TAI, the thyroid function, the absolute numbers and percentages of lymphocytes. The prevalence of thyroid function abnormality in RIF women with TAI was not significantly different from that in RIF women without TAI (c 2 = 0.484, p > 0.05). The absolute number and percentage of T cells, T helper (Th) cells, B cells and natural killer (NK) cells were not significantly different in RIF women with TAI compared to those without TAI (all p > 0.05). The percentage of T cytotoxicity (Tc) cells was significantly decreased in RIF women with TAI compared to those without TAI ( p < 0.05). Meanwhile, Th/Tc ratio was significantly increased ( p < 0.05). These results indicated that the decreased Tc percentage and increased Th/Tc ratio may be another influential factor of adverse pregnancy outcomes in RIF women with TAI.

Keywords: infertility; repeated implantation failure; thyroid autoimmunity; lymphocytes (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
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