Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B 1

Na Liang, Fengyuan Wang, Xi Peng, Jing Fang, Hengmin Cui, Zhengli Chen, Weimin Lai, Yi Zhou and Yi Geng
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Na Liang: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China
Fengyuan Wang: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China
Xi Peng: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China
Jing Fang: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China
Hengmin Cui: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China
Zhengli Chen: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China
Weimin Lai: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China
Yi Zhou: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China
Yi Geng: Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang 611130, China

IJERPH, 2015, vol. 12, issue 9, 1-13

Abstract: To evaluate the renal toxicity of dietary aflatoxin B 1 (AFB 1 ) and ameliorating effects of added dietary sodium selenite in broiler, renal histopathological changes, ultrastructural changes, and renal function parameters were monitored at 7, 14, and 21 days of age. Two hundred one-day-old healthy male Avian broilers were divided into four groups, namely control group, AFB 1 group (0.3 mg/kg AFB 1 ), +Se group (0.4 mg/kg Se), and AFB 1 +Se group (0.3 mg/kg AFB 1 +0.4 mg/kg Se). Compared with that of the control group, the relative weight of kidney was increased in the AFB 1 group. There were no significant differences between the AFB 1 +Se group and the control group. By histopathological observation, the renal epithelia were swelling and necrosis at 7 and 21 days of age. Ultrastructurally, the lipid droplets and expanded endoplasmic reticulum appeared in the plasma of epithelia cells in the AFB 1 group. Enlarged mitochondria with degenerated cristae were observed in the +Se group. Compared with the control group, the contents of serum creatinine and serum uric acid in the AFB 1 group were increased, while the activity of renal Na + -K + ATPase was decreased. When 0.4 mg/kg selenium was added into the diet containing 0.3 mg/kg AFB 1 , there were no obvious histological changes in the AFB 1 +Se group, and the contents of the serum creatinine and serum uric acid contents and the activity of renal Na + -K + ATPase were close to those in the control group. In conclusion, sodium selenite exhibited protective effects on AFB 1 -induced kidney toxicity in broilers.

Keywords: aflatoxin B 1; sodium selenite; pathological observation; ultrastructural observation; renal function; broiler (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
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