Profile of HIV-Infected Hispanics with Pancytopenia

Eduardo J. Santiago-Rodríguez, Angel M. Mayor, Diana M. Fernández-Santos and Robert F. Hunter-Mellado
Additional contact information
Eduardo J. Santiago-Rodríguez: Retrovirus Research Center, Internal Medicine Department, School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico 00960, USA
Angel M. Mayor: Retrovirus Research Center, Internal Medicine Department, School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico 00960, USA
Diana M. Fernández-Santos: Retrovirus Research Center, Internal Medicine Department, School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico 00960, USA
Robert F. Hunter-Mellado: Retrovirus Research Center, Internal Medicine Department, School of Medicine, Universidad Central del Caribe, Bayamón, Puerto Rico 00960, USA

IJERPH, 2015, vol. 13, issue 1, 1-7

Abstract: Pancytopenia is seen in late HIV infection; it is associated with medical complications and with decreased survival. We determined the prevalence of pancytopenia at baseline in a cohort of HIV-positive Hispanics living in Puerto Rico, and compared their socio-demographic, immunological and clinical characteristics. A total of 1202 patients enrolled between 2000 and 2010 were included. They were grouped according to pancytopenia status, defined by having: platelets <150,000 ?L, white cell count <4000 ?L, and hemoglobin <12 g/dL (women) or <13 g/dL (men). Differences were evaluated using Student’s t -test, Chi-square test and Kaplan-Meier method. The prevalence of pancytopenia was 8.7%. Patients with pancytopenia had lower BMI and lower CD4 count, as well as higher HIV viral load and higher proportions of unemployment, clinical AIDS and antiretroviral treatment (ART) use ( p < 0.05). One-year mortality rate was significantly higher in patients with pancytopenia (18.1% vs . 5.1%, p < 0.001). When stratifying for ART this association persisted for patients who did not receive ART (41.4% vs . 5.2%, p < 0.001), but it was not seen in patients who received treatment (9.2% vs . 5.6%, p = 0.196). Pancytopenia was associated with elements of advanced stages of HIV. ART could reduce the mortality of HIV-patients with pancytopenia to levels comparable to patients without the disorders.

Keywords: HIV; Hispanics; blood disorders; pancytopenia; antiretroviral treatment; prevalence; mortality (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2015
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/13/1/38/pdf (application/pdf)
https://www.mdpi.com/1660-4601/13/1/38/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:13:y:2015:i:1:p:38-:d:61062

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().