The Impact of Secondhand Smoke Exposure on Children with Cystic Fibrosis: A Review

Benjamin T. Kopp, Juan Antonio Ortega-García, S. Christy Sadreameli, Jack Wellmerling, Estelle Cormet-Boyaka, Rohan Thompson, Sharon McGrath-Morrow and Judith A. Groner
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Benjamin T. Kopp: Section of Pediatric Pulmonology, Nationwide Children’s Hospital, Columbus, OH 43205, USA
Juan Antonio Ortega-García: Paediatric Environmental Health Specialty Unit, Department of Pediatrics, Clinical University Hospital Virgen of Arrixaca, Murcia 30120, Spain
S. Christy Sadreameli: Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins School of Medicine, Baltimore, MD 20205, USA
Jack Wellmerling: Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Estelle Cormet-Boyaka: Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
Rohan Thompson: Section of Pediatric Pulmonology, Nationwide Children’s Hospital, Columbus, OH 43205, USA
Sharon McGrath-Morrow: Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins School of Medicine, Baltimore, MD 20205, USA
Judith A. Groner: Section of Ambulatory Pediatrics, Nationwide Children’s Hospital, Columbus, OH 43205, USA

IJERPH, 2016, vol. 13, issue 10, 1-10

Abstract: Secondhand smoke exposure (SHSe) has multiple adverse effects on lung function and growth, nutrition, and immune function in children; it is increasingly being recognized as an important modifier of disease severity for children with chronic diseases such as cystic fibrosis (CF). This review examines what is known regarding the prevalence of SHSe in CF, with the majority of reviewed studies utilizing parental-reporting of SHSe without an objective biomarker of exposure. A wide range of SHSe is reported in children with CF, but under-reporting is common in studies involving both reported and measured SHSe. Additionally, the impact of SHSe on respiratory and nutritional health is discussed, with potential decreases in long-term lung function, linear growth, and weight gain noted in CF children with SHSe. Immunologic function in children with CF and SHSe remains unknown. The impact of SHSe on cystic fibrosis transmembrane conductance regulator (CFTR) function is also examined, as reduced CFTR function may be a pathophysiologic consequence of SHSe in CF and could modulate therapeutic interventions. Finally, potential interventions for ongoing SHSe are delineated along with recommended future areas of study.

Keywords: tobacco; cystic fibrosis; pediatric (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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