Polymorphisms of HLA-DM on Treatment Response to Interferon/Ribavirin in Patients with Chronic Hepatitis C Virus Type 1 Infection

Hongbo Chen, Yinan Yao, Yifan Wang, Hua Zhou, Tianxiang Xu, Jing Liu, Guocheng Wang, Yongfeng Zhang, Xiang Chen, Qingwei Liu, Peng Huang and Rongbin Yu
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Hongbo Chen: Department of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, China
Yinan Yao: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Yifan Wang: Department of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, China
Hua Zhou: Department of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, China
Tianxiang Xu: Department of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, China
Jing Liu: Department of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, China
Guocheng Wang: Department of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, China
Yongfeng Zhang: Department of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, China
Xiang Chen: Department of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, China
Qingwei Liu: Department of Infectious Disease, the Jurong People’s Hospital, Jurong 212400, China
Peng Huang: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China
Rongbin Yu: Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 211166, China

IJERPH, 2016, vol. 13, issue 10, 1-8

Abstract: Background: HLA-DM gene, which is related to antigen processing and presentation and located in the non-classical class-II region of human leukocyte antigen (HLA) region, may play a crucial role in chronic hepatitis C virus (HCV) infection treatment outcomes. The study was conducted to evaluate the role of the variant of several single nucleotide polymorphisms (SNPs) in HLA-DM gene in HCV treatment outcomes. Methods: We genotyped four SNPs from the candidate genes ( HLA-DMA and DMB ) in 336 patients who were treated with pegylated interferon-alpha and ribavirin (PEG IFN-?/RBV). Multivariate analysis of factors predicting sustained virological response (SVR) was conducted. Results: HLA-DMA rs1063478 and DMB rs23544 were independent factors of HCV treatment outcomes in Chinese Han population. Individuals who carried favorable genotypes of rs1063478TT and rs23544GG were more likely to achieve SVR {Dominant model: odds ratio (OR) = 2.05, 95% confidence interval (CI) = 1.24–3.41; OR = 2.04, 95% CI =1.23–3.35, respectively}. Rs23544, rs1063478, baseline glucose, baseline platelet and T4 level were independent predictors of SVR. The area under the receiver operating characteristic (ROC) curve (AUC) was 0.740. Conclusions: The genetic variation of rs1063478 and rs23544 are associated with the treatment outcomes in the Chinese Han population.

Keywords: hepatitis C; genetic polymorphism; HLA-DM gene; treatment outcome (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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