l -Arginine Enhances Resistance against Oxidative Stress and Heat Stress in Caenorhabditis elegans

Heran Ma, Yudan Ma, Zhixian Zhang, Ziyuan Zhao, Ran Lin, Jinming Zhu, Yi Guo and Li Xu
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Heran Ma: Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China
Yudan Ma: Sports Science Research Institute of Jilin Province, Changchun 130022, China
Zhixian Zhang: Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China
Ziyuan Zhao: Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China
Ran Lin: Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China
Jinming Zhu: The China-Japan Union Hospital of Jilin University, Changchun 130033, China
Yi Guo: Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China
Li Xu: Key laboratory for Molecular Enzymology and Engineering, The Ministry of Education, National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, China

IJERPH, 2016, vol. 13, issue 10, 1-9

Abstract: The antioxidant properties of l -arginine ( l -Arg) in vivo, and its effect on enhancing resistance to oxidative stress and heat stress in Caenorhabditis elegans were investigated. C. elegans , a worm model popularly used in molecular and developmental biology, was used in the present study. Here, we report that l -Arg, at a concentration of 1 mM, prolonged C. elegans life by 26.98% and 37.02% under oxidative and heat stress, respectively. Further experiments indicated that the longevity-extending effects of l -Arg may be exerted by its free radical scavenging capacity and the upregulation of aging-associated gene expression in worms. This work is important in the context of numerous recent studies that concluded that environment stresses are associated with an increased population death rate.

Keywords: C. elegans; l -Arg; antiaging; antioxidant; free radical (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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