Ferritin Level Is Positively Associated with Chronic Kidney Disease in Korean Men, Based on the 2010–2012 Korean National Health and Nutrition Examination Survey

Hee-Taik Kang, John A. Linton, Soon Kil Kwon, Byoung-Jin Park and Jong Hun Lee
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Hee-Taik Kang: Department of Family Medicine, College of Medicine, Chungbuk National University, Chungbuk 28644, Korea
John A. Linton: Department of Family Medicine, Severance Hospital, Yonsei University, Seoul 03722, Korea
Soon Kil Kwon: Division of Nephrology, Department of Internal Medicine, College of Medicine, Chungbuk National University, Chungbuk 28644, Korea
Byoung-Jin Park: Department of Family Medicine, Yongin Severance Hospital, Yonsei University, Yongin 17046, Korea
Jong Hun Lee: Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam-si 13488, Korea

IJERPH, 2016, vol. 13, issue 11, 1-9

Abstract: (1) Background: Oxidative stress and inflammation are associated with higher risk of chronic kidney disease (CKD). Serum ferritin concentrations correlate with total iron levels and systemic inflammation. (2) Methods: This study was cross-sectionally designed, based on the 2010–2012 Korean National Health and Nutrition Examination Survey (KNHANES). According to ferritin values, 13,462 participants (6082 men and 7380 women) were categorized into the normal- and high-ferritin groups (cut-off points: 200 ng/mL in men, 150 ng/mL in women). (3) Results: The mean ages of men and women were 44.5 and 48.4 years, respectively. The percentage of participants categorized into the high-ferritin group was 15.1% for men and 3.6% for women. The estimated glomerular filtration rate levels in the normal- and high-ferritin groups were 93.2 and 93.8 mL/min/1.73 m 2 for men and 97.1 and 87.7 mL/min/1.73 m 2 for women, respectively. The prevalence of CKD in the normal- and high-ferritin groups was 2.6% and 3.9% for men and 3.2% and 8.1% for women, respectively. Compared with the normal-ferritin group, the odds ratios (95% confidence intervals) for CKD of the high-ferritin group were 1.573 (1.014–2.441) in men and 1.061 (0.381–2.955) in women, after adjustments for age and other covariates. (4) Conclusions: High ferritin levels were associated with a higher risk of CKD in men but not in women.

Keywords: ferritin; oxidative stress; inflammation; chronic kidney disease; iron (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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