Diabetes and Obesity as Independent Risk Factors for Osteoporosis: Updated Results from the ROIS/EMEROS Registry in a Population of Five Thousand Post-Menopausal Women Living in a Region Characterized by Heavy Environmental Pressure

Cosimo Neglia, Alberto Argentiero, Giovanna Chitano, Nadia Agnello, Roberta Ciccarese, Antonella Vigilanza, Valerio Pantile, Domenico Argentiero, Raffaele Quarta, Matteo Rivezzi, Gian Luca Di Tanna, Carolina Di Somma, Alberto Migliore, Giovanni Iolascon, Francesca Gimigliano, Alessandro Distante and Prisco Piscitelli
Additional contact information
Cosimo Neglia: ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy
Alberto Argentiero: ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy
Giovanna Chitano: ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy
Nadia Agnello: ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy
Roberta Ciccarese: ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy
Antonella Vigilanza: ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy
Valerio Pantile: ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy
Domenico Argentiero: ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy
Raffaele Quarta: ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy
Matteo Rivezzi: IOS, Southern Italy Hospital Institute, Medicina Futura Research, Naples 80100, Italy
Gian Luca Di Tanna: Centre for Primary Care and Public Health, Queen Mary University of London, London E1 4NS, UK
Carolina Di Somma: IRCCS SDN Istituto di Ricerca Diagnostica e Nucleare, Naples 80133, Italy
Alberto Migliore: St. Peter’s Fatebenefratelli Hospital, Rome 00186, Italy
Giovanni Iolascon: Department of Orthopaedic Surgery and Rehabilitation, Second University of Naples, Naples 81100, Italy
Francesca Gimigliano: Department of Orthopaedic Surgery and Rehabilitation, Second University of Naples, Naples 81100, Italy
Alessandro Distante: ISBEM (Istituto Scientifico Biomedico Euro Mediterraneo), Brindisi 72100, Italy
Prisco Piscitelli: IOS, Southern Italy Hospital Institute, Medicina Futura Research, Naples 80100, Italy

IJERPH, 2016, vol. 13, issue 11, 1-11

Abstract: Objectives : We aimed to analyze bone mineralization and the effect of different risk factors for osteoporosis in postmenopausal women. Methods : We found 4909 postmenopausal subjects within ?10,000 records from the ROIS/EMEROS (Ionian and Salento Osteoporosis Registry/Euro Mediterranean Registry of Osteoporosis) registry, a population study carried out in an area characterized by heavy environmental pressure between Brindisi and Taranto from 2009 to 2016. All subjects were assessed via phalangeal quantitative ultrasound (QUS) to evaluate their bone mineralization (assessed via amplitude dependent speed of sound (AD-SoS)) and the association between demineralization and the presence of other conditions or risk factors. Results : Mean age was 64 ± 9.5 years and mean body mass index (BMI) was 28.7 ± 3.5 kg/m 2 . Pearson correlation analyses revealed a negative association between bone mineralization (AD-SoS) and BMI ( p < 0.001). By using multivariate logistic regression analysis, we observed significant values of odds ratios (ORs) of osteoporosis (adjusted for age, physical activity, and the use of drugs known to increase the risk of fractures) in subjects with diabetes and obesity: 1.39 (confidence interval (CI): 1.05–1.83) and 1.46 (CI: 1.20–1.78), respectively. A statistically significant linear trend of higher ORs of osteoporosis was found for increasing values of BMI. Conclusions : Our study confirmed the high impact of obesity and type 1 and type 2 diabetes on osteoporosis.

Keywords: diabetes; obesity; environmental factors; osteoporosis; fractures; quantitative ultrasounds (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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