Effects of Di-(2-ethylhexyl) Phthalate on Lipid Metabolism by the JAK/STAT Pathway in Rats

Yiyang Jia, Te Liu, Liting Zhou, Jian Zhu, Juan Wu, Di Sun, Jin Xu, Qi Wang, Huaiji Chen, Feng Xu, Yuezhu Zhang, Tianrong Zhang, Hongbo Liu and Lin Ye
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Yiyang Jia: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Te Liu: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Liting Zhou: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Jian Zhu: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Juan Wu: Cancer Center, Tumor Hospital of Jiangxi Province, Nanchang 330029, China
Di Sun: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Jin Xu: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Qi Wang: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Huaiji Chen: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Feng Xu: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Yuezhu Zhang: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Tianrong Zhang: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Hongbo Liu: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China
Lin Ye: Department of Occupational and Environmental Health, School of Public Health, Jilin University, Changchun 130021, China

IJERPH, 2016, vol. 13, issue 11, 1-16

Abstract: The most widely used plasticizer, di-(2-ethylhexyl) phthalate (DEHP), is known to affect lipid metabolism and adipogenesis. We studied the effects of dietary DEHP exposure on metabolism in rats as well as the role of the JAK/STAT pathway in this process. Eighty rats were exposed to DEHP (0, 5, 50 and 500 mg/kg/d) through dietary intake for 4 weeks. We then collected blood samples, liver, and adipose tissues to detect modifications in the levels of serum lipids, leptin, adiponectin and insulin. JAK3, STAT5a and PPAR? expression were detected at both the gene and protein levels. The activation of JAK3 and STAT5a was also detected. The DEHP-exposed rats had increased body weight, serum lipid, insulin, and leptin levels. Moreover, the JAK3/STAT5a pathway was activated in the adipose tissue; however, this pathway was not activated in the liver. The mRNA of SREBP-1c in the liver was increased significantly among each of the groups, in contrast to the levels found in the mature SREBP-1c protein form. Furthermore, the expression of FABP4 , Acox and FASn was decreased in the liver, but increased in adipose tissue. Thus, we conclude that exposure to DEHP reduces the hydrolysis of lipid and promotes triglyceride accumulation by oppositely regulating the activation state of JAK/STAT pathway in the liver and adipose tissue, resulting in the disorder of body lipid metabolism and obesity.

Keywords: di-(2-ethylhexyl) phthalate; JAK/STAT; lipid metabolism; adipose tissue (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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