MiRNAs and miRNA Polymorphisms Modify Drug Response

Mu-Peng Li, Yao-Dong Hu, Xiao-Lei Hu, Yan-Jiao Zhang, Yong-Long Yang, Chun Jiang, Jie Tang and Xiao-Ping Chen
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Mu-Peng Li: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Yao-Dong Hu: Department of Cardiology, Heping Hospital Affiliated to Changzhi Medical College, Changzhi 046000, China
Xiao-Lei Hu: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Yan-Jiao Zhang: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Yong-Long Yang: Haikou People’s Hospital and Affiliated Haikou Hospital of Xiangya Medical School, Central South University, Haikou 570311, China
Chun Jiang: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Jie Tang: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
Xiao-Ping Chen: Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China

IJERPH, 2016, vol. 13, issue 11, 1-22

Abstract: Differences in expression of drug response-related genes contribute to inter-individual variation in drugs’ biological effects. MicroRNAs (miRNAs) are small noncoding RNAs emerging as new players in epigenetic regulation of gene expression at post-transcriptional level. MiRNAs regulate the expression of genes involved in drug metabolism, drug transportation, drug targets and downstream signal molecules directly or indirectly. MiRNA polymorphisms, the genetic variations affecting miRNA expression and/or miRNA-mRNA interaction, provide a new insight into the understanding of inter-individual difference in drug response. Here, we provide an overview of the recent progress in miRNAs mediated regulation of biotransformation enzymes, drug transporters, and nuclear receptors. We also describe the implications of miRNA polymorphisms in cancer chemotherapy response.

Keywords: microRNA; drug response; miRNA polymorphisms; prognosis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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