Secondhand Smoke Is an Important Modifiable Risk Factor in Sickle Cell Disease: A Review of the Current Literature and Areas for Future Research

S. Christy Sadreameli, Benjamin T. Kopp, Susan E. Creary, Michelle N. Eakin, Sharon McGrath-Morrow and John J. Strouse
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S. Christy Sadreameli: Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Benjamin T. Kopp: Section of Pediatric Pulmonology, Nationwide Children’s Hospital, Columbus, OH 43205, USA
Susan E. Creary: Division of Pediatric Hematology/Oncology/BMT, Nationwide Children’s Hospital, Columbus, OH 43205, USA
Michelle N. Eakin: Division of Pulmonary and Critical Care Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
Sharon McGrath-Morrow: Eudowood Division of Pediatric Respiratory Sciences, Johns Hopkins School of Medicine, Baltimore, MD 21287, USA
John J. Strouse: Divisions of Hematology and Pediatric Hematology/Oncology, Duke University School of Medicine, Durham, NC 27710, USA

IJERPH, 2016, vol. 13, issue 11, 1-13

Abstract: Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that causes significant morbidity and mortality related to chronic hemolytic anemia, vaso-occlusion, and resultant end-organ damage. Tobacco smoke exposure (TSE) through secondhand smoke exposure in people with SCD of all ages and through primary smoking in adolescents and adults is associated with significantly increased morbidity, with increased rates of emergency department visits and hospitalizations for painful vaso-occlusive crises and acute chest syndrome (ACS). Secondhand smoke is also associated with pulmonary function abnormalities in children with SCD who are already at risk for pulmonary function abnormalities on the basis of SCD. TSE is emerging as one of the few modifiable risk factors of SCD. This review discusses the current state of the evidence with respect to TSE and SCD morbidity, discusses potential mechanisms, and highlights current gaps in the evidence and future research directions.

Keywords: secondhand smoke; environmental tobacco smoke; tobacco; sickle cell disease; pulmonary function tests (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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