The Association between Arrhythmia and Helicobacter pylori Infection: A Meta-Analysis of Case-Control Studies

Jin Yan, Qiang She, Yifeng Zhang, Chang Cui and Guoxin Zhang
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Jin Yan: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
Qiang She: The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China
Yifeng Zhang: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China
Chang Cui: The First Clinical Medical College, Nanjing Medical University, Nanjing 210029, China
Guoxin Zhang: Department of Gastroenterology, The First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China

IJERPH, 2016, vol. 13, issue 11, 1-11

Abstract: Arrhythmia is a common disease around the world and Helicobacter pylori ( H. pylori ) is a bacterium infecting 28% to 84% of subjects, depending on the population tested. However, the implication of H. pylori in cardiac arrhythmia is poorly understood. We performed this meta-analysis with an aim to identify the association between arrhythmia and H. pylori . We searched PubMed, Embase, Web of Science, and the Cochrane library databases to select studies on the association between arrhythmia and H. pylori . In the arrhythmia group, 392 (58.1%) were H. pylori -positive and in the control group 640 (47.8%) were H. pylori -positive. Compared to the controls, the infection rate of H. pylori was higher in patients with arrhythmia than in controls (odds ratio (OR) = 1.797, 95% confidence interval (CI): 1.081–2.988, p < 0.05). Subgroup analysis indicated that H. pylori infection was a risk factor for atrial fibrillation in Asia and Africa. Therefore, a correlation between H. pylori infection and arrhythmia may exist and H. pylori eradication may decrease the occurrence of arrhythmia, especially in Asia and Africa.

Keywords: Helicobacter pylori; arrhythmia; meta-analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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