Sub-Acute Toxicity Study of Graphene Oxide in the Sprague-Dawley Rat

Yingbo Li, Yan Wang, Liu Tu, Di Chen, Zhi Luo, Dengyuan Liu, Zhuang Miao, Gang Feng, Li Qing and Shali Wang
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Yingbo Li: Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China
Yan Wang: Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China
Liu Tu: Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China
Di Chen: Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China
Zhi Luo: Preventive Medicine, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
Dengyuan Liu: Preventive Medicine, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
Zhuang Miao: Preventive Medicine, School of Public Health and Management, Chongqing Medical University, Chongqing 400016, China
Gang Feng: Pediatric Specialty of Clinical Medicine, Academy of Pediatrics, Chongqing Medical University, Chongqing 400016, China
Li Qing: The First Clinical College of Chongqing Medical University, Chongqing 400016, China
Shali Wang: Cerebrovascular Diseases Laboratory, Institute of Neuroscience, Chongqing Medical University, Chongqing 400016, China

IJERPH, 2016, vol. 13, issue 11, 1-13

Abstract: Graphene oxide (GO) is an oxidized derivative of graphene used in biotechnology and medicine. The safety of GO is uncertain, so we evaluated its toxicity in male rats. Rat tail veins were injected with 2.5, 5, or 10 mg/kg GO for seven days and behavioral patterns, pathology, and tissue morphology were assessed. Data show that behaviors were not altered according to an open field test and a functional observational battery test, but histopathological analysis indicated that GO caused inflammation of the lung, liver, and spleen. GO also reduced cholesterol, high density lipoprotein (HDL), and low density lipoprotein (LDL). No other organs were modified. Thus, high concentrations of GO are toxic for the lung, liver, and spleen, but the mechanism by which this occurs requires more study.

Keywords: graphene oxide; carbon nano-material; sub-acute toxicology (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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