Effects of Fetal Exposure to Asian Sand Dust on Development and Reproduction in Male Offspring

Seiichi Yoshida, Takamichi Ichinose, Keiichi Arashidani, Miao He, Hirohisa Takano and Takayuki Shibamoto
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Seiichi Yoshida: Department of Health and Sciences, Oita University of Nursing and Health Sciences, Oita 870-1201, Japan
Takamichi Ichinose: Department of Health and Sciences, Oita University of Nursing and Health Sciences, Oita 870-1201, Japan
Keiichi Arashidani: Department of Immunology and Parasitology, School of Medicine, University of Occupational and Environmental Health, Fukuoka 807-8555, Japan
Miao He: Environment and Non-Communicable Disease Research Center, School of Public Health, China Medical University, Shenyang 110122, China
Hirohisa Takano: Environmental Health Division, Department of Environmental Engineering, Graduate School of Engineering, Kyoto University, Kyoto 615-8540, Japan
Takayuki Shibamoto: Department of Environmental Toxicology, University of California, Davis, CA 95616, USA

IJERPH, 2016, vol. 13, issue 11, 1-9

Abstract: In recent experimental studies, we reported the aggravating effects of Asian sand dust (ASD) on male reproduction in mice. However, the effects of fetal ASD exposure on male reproduction have not been investigated. The present study investigated the effects of fetal ASD exposure on reproduction in male offspring. Using pregnant CD-1 mice, ASD was administered intratracheally on days 7 and 14 of gestation, and the reproduction of male offspring was determined at 5, 10, and 15 weeks after birth. The secondary sex ratio was significantly lower in the fetal ASD-exposed mice than in the controls. Histologic examination showed partial vacuolation of seminiferous tubules in immature mice. Moreover, daily sperm production (DSP) was significantly less in the fetal ASD-exposed mice than in the controls. DSP in the fetal ASD-exposed mice was approximately 10% less than the controls at both 5 and 10 weeks. However, both the histologic changes and the DSP decrease were reversed as the mice matured. These findings suggest that ASD exposure affects both the fetal development and the reproduction of male offspring. In the future, it will be necessary to clarify the onset mechanisms of ASD-induced male fetus death and male reproductive disorders.

Keywords: Asian sand dust; in utero exposure; secondary sex ratio; male reproduction; daily sperm production (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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