Recent Advances on Inorganic Nanoparticle-Based Cancer Therapeutic Agents

Fenglin Wang, Chengyao Li, Jing Cheng and Zhiqin Yuan
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Fenglin Wang: School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China
Chengyao Li: School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China
Jing Cheng: Hunan Key Laboratory of Food Safety Science & Technology, Technology Center of Hunan Entry-Exit Inspection and Quarantine Bureau, Hunan Academy of Inspection and Quarantine, Changsha 410004, China
Zhiqin Yuan: State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China

IJERPH, 2016, vol. 13, issue 12, 1-15

Abstract: Inorganic nanoparticles have been widely investigated as therapeutic agents for cancer treatments in biomedical fields due to their unique physical/chemical properties, versatile synthetic strategies, easy surface functionalization and excellent biocompatibility. This review focuses on the discussion of several types of inorganic nanoparticle-based cancer therapeutic agents, including gold nanoparticles, magnetic nanoparticles, upconversion nanoparticles and mesoporous silica nanoparticles. Several cancer therapy techniques are briefly introduced at the beginning. Emphasis is placed on how these inorganic nanoparticles can provide enhanced therapeutic efficacy in cancer treatment through site-specific accumulation, targeted drug delivery and stimulated drug release, with elaborations on several examples to highlight the respective strategies adopted. Finally, a brief summary and future challenges are included.

Keywords: cancer therapeutic agents; gold nanoparticles; magnetic nanoparticles; upconversion nanoparticles; mesoporous silica nanoparticles (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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