Immunogenetic Markers Definition in Latvian Patients with Lyme Borreliosis and Lyme Neuroborreliosis

Lilija Kovalchuka, Svetlana Cvetkova, Julija Trofimova, Jelena Eglite, Sandra Gintere, Irina Lucenko, Barbara Oczko-Grzesik, Ludmila Viksna and Angelika Krumina
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Lilija Kovalchuka: Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia
Svetlana Cvetkova: Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia
Julija Trofimova: Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia
Jelena Eglite: Laboratory of Clinical Immunology and Immunogenetic, Riga Stradiņš University, Riga LV-1067, Latvia
Sandra Gintere: Department of Family Medicine, Riga Stradiņš University, Riga LV-1067, Latvia
Irina Lucenko: Centre for Disease Prevention and Control of Latvia, Riga LV-1005, Latvia
Barbara Oczko-Grzesik: Department of Infectious Diseases, Medical University of Silesia, 40-055 Katowice, Poland
Ludmila Viksna: Department of Infectology and Dermatology, Riga Stradiņš University, Riga LV-1006, Latvia
Angelika Krumina: Institute of Food Safety, Animal Health and Environment BIOR, Riga LV-1076, Latvia

IJERPH, 2016, vol. 13, issue 12, 1-11

Abstract: The aim of this study was to determine the human leukocyte antigen (HLA)-DRB1 alleles in two groups of patients in Latvia: patients with Lyme borreliosis and patients with Lyme neuroborreliosis. The study included 216 patients with Lyme borreliosis, 29 patients with Lyme neuroborreliosis and 282 control persons. All surveyed persons were residents of Latvia. The HLA-DR genotyping was performed by polymerase chain reaction- sequence specific primer (PCR-SSP). The predisposition to the Lyme borreliosis is associated with the HLA-DRB1*07, -DRB1*17(03), -DRB1*04, -DRB1*15(02) alleles. The allele -DRB1*11(05), -DRB1*14(06) and -DRB1*13(06) were significantly more frequent in controls. In-group with Lyme neuroborreliosis differences were found for the -DRB1*07 and -DRB1*04 alleles, but only HLA-DRB1*07 allele was statistically significant after Bonferroni correction and associated with Lyme neuroborreliosis in Latvian patients.

Keywords: Borrelia burgdorferi; Lyme borreliosis; Lyme neuroborreliosis; immunogenetic markers; HLA-DRB1 (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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