Additive Interaction of MTHFR C677T and MTRR A66G Polymorphisms with Being Overweight/Obesity on the Risk of Type 2 Diabetes

Xueyuan Zhi, Boyi Yang, Shujun Fan, Yongfang Li, Miao He, Da Wang, Yanxun Wang, Jian Wei, Quanmei Zheng and Guifan Sun
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Xueyuan Zhi: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China
Boyi Yang: Guangzhou Key Laboratory of Environmental Pollution and Health Risk Assessment, Department of Preventive Medicine, School of Public Health, Sun Yat-Sen University, Guangzhou 510080, China
Shujun Fan: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China
Yongfang Li: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China
Miao He: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China
Da Wang: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China
Yanxun Wang: Division of Molecular Preventive Medicine, Shanghai Institute of Targeted Therapy and Molecular Medicine, Shanghai 200433, China
Jian Wei: Brain Disease Center, Tianjin Dagang Oil Field General Hospital, Tianjin 300280, China
Quanmei Zheng: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China
Guifan Sun: Research Center of Environment and Non-Communicable Disease, School of Public Health, China Medical University, Shenyang 110122, China

IJERPH, 2016, vol. 13, issue 12, 1-11

Abstract: Although both methylenetetrahydrofolate reductase ( MTHFR ) C677T and methionine synthase reductase ( MTRR ) A66G polymorphisms have been associated with type 2 diabetes (T2D), their interactions with being overweight/obesity on T2D risk remain unclear. To evaluate the associations of the two polymorphisms with T2D and their interactions with being overweight/obesity on T2D risk, a case-control study of 180 T2D patients and 350 healthy controls was conducted in northern China. Additive interaction was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP) and synergy index (S). After adjustments for age and gender, borderline significant associations of the MTHFR C677T and MTRR A66G polymorphisms with T2D were observed under recessive (OR = 1.43, 95% CI: 0.98–2.10) and dominant (OR = 1.43, 95% CI: 1.00–2.06) models, respectively. There was a significant interaction between the MTHFR 677TT genotype and being overweight/obesity on T2D risk (AP = 0.404, 95% CI: 0.047–0.761), in addition to the MTRR 66AG/GG genotypes (RERI = 1.703, 95% CI: 0.401–3.004; AP = 0.528, 95% CI: 0.223–0.834). Our findings suggest that individuals with the MTHFR 677TT or MTRR 66AG/GG genotypes are more susceptible to the detrimental effect of being overweight/obesity on T2D. Further large-scale studies are still needed to confirm our findings.

Keywords: MTHFR C677T; MTRR A66G; overweight; obesity; type 2 diabetes; additive interaction (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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