Association between CRP and TNF-? genes Variants and Cardiovascular Heart Disease in a Mexican Population: Protocol for a Case-Control Study

Yazmín Hernández-Díaz, Carlos Alfonso Tovilla-Zárate, Isela Juárez-Rojop, María Lilia López-Narváez, José Francisco Álvarez-Cámara and Thelma Beatriz González-Castro
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Yazmín Hernández-Díaz: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco 86205, México
Carlos Alfonso Tovilla-Zárate: División Multidisciplinaria de Comalcalco, Universidad Juárez Autónoma de Tabasco, Comalcalco, Tabasco 86650, México
Isela Juárez-Rojop: División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco Villahermosa, Tabasco 86150, México
María Lilia López-Narváez: Hospital General de Yajalón. Secretaría de Salud, Yajalón, Chiapas 29932, México
José Francisco Álvarez-Cámara: División Académica de Ciencias de la Salud, Universidad Juárez Autónoma de Tabasco Villahermosa, Tabasco 86150, México
Thelma Beatriz González-Castro: División Académica Multidisciplinaria de Jalpa de Méndez, Universidad Juárez Autónoma de Tabasco, Jalpa de Méndez, Tabasco 86205, México

IJERPH, 2016, vol. 13, issue 1, 1-8

Abstract: Background: The C-reactive protein ( CRP ) and the tumor necrosis factor-alpha ( TNF-? ) are considered markers of inflammation and have been shown to predict the risk of incident cardiovascular events. However, few studies have undertaken a comprehensive examination of SNPs (single nucleotide polymorphisms) of the CRP and TNF-? genes; due to this, we will present a protocol study to evaluate the role of the CRP and TNF-? genes in Mexican individuals. Methods/design: we will perform a case-control study to explore the CRP and TNF-? genotype distribution as well as the serum influence of rs1800947, rs1130864, rs2794521 and rs1205 (polymorphisms of the CRP gene) and rs361525, rs1800629, rs1799724, rs1800630, rs1799964 (of the TNF-? gene) in Mexican individuals who present coronary artery disease. Ethics and dissemination: a written informed consent will be obtained from all the participating subjects. An article detailing the results of the study will be submitted for publication in an international peer-reviewed journal, in accordance with STROBE criteria.

Keywords: CAD; CRP; TNF-?; association studies; Mexican population (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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