Maternal and Neonatal Levels of Perfluoroalkyl Substances in Relation to Gestational Weight Gain

Jillian Ashley-Martin, Linda Dodds, Tye E. Arbuckle, Anne-Sophie Morisset, Mandy Fisher, Maryse F. Bouchard, Gabriel D. Shapiro, Adrienne S. Ettinger, Patricia Monnier, Renee Dallaire, Shayne Taback and William Fraser
Additional contact information
Jillian Ashley-Martin: Perinatal Epidemiology Research Unit, IWK Health Centre, Halifax, NS B3K 6R8, Canada
Linda Dodds: Department of Obstetrics and Gynecology, Dalhousie University, Halifax, NS B3K 6R8, Canada
Tye E. Arbuckle: Health Canada, Ottawa, ON K1A 0K9, Canada
Anne-Sophie Morisset: Sainte Justine Hospital Research Center, University of Montreal, Montreal, PQ H3T 1C5, Canada
Mandy Fisher: Health Canada, Ottawa, ON K1A 0K9, Canada
Maryse F. Bouchard: Department of Environmental and Occupational Health, University of Montreal, Montreal, PQ H3T 1A8, Canada
Gabriel D. Shapiro: Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, PQ H3A 1A2, Canada
Adrienne S. Ettinger: Departmentof Nutritional Sciences, University of Michigan School of Public Health, Ann Arbor, MI 48109, USA
Patricia Monnier: Department of Obstetrics and Gynecology, McGill University, Montreal, PQ H3A 1A1, Canada
Renee Dallaire: Faculty of Medicine, Laval University, Quebec City, PQ G1V 0A6, Canada
Shayne Taback: Departments of Pediatrics and Child Health, University of Manitoba, Winnipeg, MB R3E 3P4, Canada
William Fraser: Departments of Obstetrics and Gynecology, University of Sherbrooke, Sherbrooke, PQ J1H 5N4, Canada

IJERPH, 2016, vol. 13, issue 1, 1-11

Abstract: Perfluoroalkyl substances (PFASs) are ubiquitous, persistent pollutants widely used in the production of common household and consumer goods. There is a limited body of literature suggesting that these chemicals may alter metabolic pathways and growth trajectories. The relationship between prenatal exposures to these chemicals and gestational weight gain (GWG) has received limited attention. One objective was to analyze the associations among maternal plasma levels of three common perfluoroalkyl substances (perfluorooctanoate (PFOA), perfluorooctanesulfonate (PFOS), perfluorohexanesulfanoate (PFHxS)) and GWG. Additionally, we explored whether GWG was associated with cord blood PFAS levels. This study utilized data collected in the Maternal-Infant Research on Environmental Chemicals (MIREC) Study, a trans-Canada cohort study of 2001 pregnant women. Our analysis quantified associations between (1) maternal PFAS concentrations and GWG and (2) GWG and cord blood PFAS concentrations. Maternal PFOS concentrations were positively associated with GWG ( ? = 0.39 95% CI: 0.02, 0.75). Interquartile increases in GWG were significantly associated with elevated cord blood PFOA (OR = 1.33; 95% CI: 1.13 to 1.56) and PFOS (OR = 1.20; 95% CI: 1.03 to 1.40) concentrations. No statistically significant associations were observed between GWG and either measure of PFHxS. These findings warrant elucidation of the potential underlying mechanisms.

Keywords: perfluoroalkyl substances; gestational weight gain; environmental contaminants; birth cohort (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations: View citations in EconPapers (3)

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