Divergent Effects of Arsenic on NF-?B Signaling in Different Cells or Tissues: A Systematic Review and Meta-Analysis

Meng Wei, Jiaming Liu, Mengchuan Xu, Dongsheng Rui, Shangzhi Xu, Gangling Feng, Yusong Ding, Shugang Li and Shuxia Guo
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Meng Wei: Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China
Jiaming Liu: Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China
Mengchuan Xu: Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China
Dongsheng Rui: Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China
Shangzhi Xu: Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China
Gangling Feng: Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China
Yusong Ding: Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China
Shugang Li: Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China
Shuxia Guo: Department of Public Health, Shihezi University School of Medicine, Shihezi 832000, Xinjiang, China

IJERPH, 2016, vol. 13, issue 2, 1-16

Abstract: Arsenic is ubiquitously present in human lives, including in the environment and organisms, and has divergent effects between different cells and tissues and between different exposure times and doses. These observed effects have been attributed to the nuclear transcription factor kappa B(NF-?B) signaling pathway. Herein, a meta-analysis was performed by independently searching databases including the Cochrane Library, PubMed, Springer, Embase, and China National Knowledge Infrastructure, to analyze effects of arsenic exposure on NF-?B signaling. Compared to controls, in the exposed group, p-I?B levels were found to be 8.13-fold higher (95% CI, 2.40–13.85; Z = 2.78; p = 0.005), I?B levels were 16.19-fold lower (95% CI, ?27.44–?4.94; Z = 2.78; p = 0.005), and NF-?Bp65 levels were 0.77-fold higher (95% CI, 0.13–1.42; Z = 2.34; p = 0.02) for normal cells and tissue, while NF-?Bp65 levels were 4.90-fold lower (95% CI, ?8.49–1.31; Z = 2.62; p = 0.009), NF-?B activity was 2.45-fold lower (95% CI, ?3.66–1.25; Z = 4.00; p < 0.0001), and DNA-binding activity of NF-?B was 9.75-fold lower (95% CI, ?18.66–4.54; Z = 2.15; p = 0.03) for abnormal cells and tissue. Short exposure to high arsenic doses activated the NF-?B signaling pathway, while long exposure to low arsenic doses suppressed NF-?B signaling pathway activation. These findings may provide a theoretical basis for injurious and therapeutic mechanisms of divergent effects of arsenic.

Keywords: arsenic; NF-?B; meta-analysis (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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