Environmental Exposure to Triclosan and Semen Quality

Wenting Zhu, Hao Zhang, Chuanliang Tong, Chong Xie, Guohua Fan, Shasha Zhao, Xiaogang Yu, Ying Tian and Jun Zhang
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Wenting Zhu: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Hao Zhang: MOE and Shanghai Key Laboratory of Children’s Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Chuanliang Tong: Department of Science and Research, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China
Chong Xie: Department of Andrology, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China
Guohua Fan: Department of Andrology, International Peace Maternity and Child Health Hospital of China Welfare Institute, Shanghai 200030, China
Shasha Zhao: MOE and Shanghai Key Laboratory of Children’s Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Xiaogang Yu: MOE and Shanghai Key Laboratory of Children’s Environment Health, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China
Ying Tian: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
Jun Zhang: School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China

IJERPH, 2016, vol. 13, issue 2, 1-12

Abstract: Triclosan (2,4,4?-trichloro-2?-hydroxy-diphenyl ether, TCS) is widely used in personal care, household, veterinary and industrial products. It was considered as a potential male reproductive toxicant in previous in vitro and in vivo studies. However, evidence from human studies is scarce. Our study aims to investigate the relationship between TCS exposure and semen quality. We measured urinary TCS concentrations in 471 men recruited from a male reproductive health clinic. TCS was detected in 96.7% of urine samples, with a median concentration of 0.97 ng (mg·creatinine) ?1 (interquartile range, 0.41–2.95 ng (mg·creatinine) ?1 ). A multiple linear regression analysis showed a negative association between natural logarithm (Ln) transformed TCS concentration (Ln-TCS) and Ln transformed number of forward moving sperms (adjusted coefficient ? = ?0.17; 95% confidence interval (CI) (?0.32, ?0.02). Furthermore, among those with the lowest tertile of TCS level, Ln-TCS was negatively associated with the number of forward moving sperms (? = ?0.35; 95% CI (?0.68, ?0.03)), percentage of sperms with normal morphology (? = ?1.64; 95% CI (?3.05, ?0.23)), as well as number of normal morphological sperms, sperm concentration and count. Our findings suggest that the adverse effect of TCS on semen quality is modest at the environment-relevant dose in humans. Further studies are needed to confirm our findings.

Keywords: cross-sectional study; semen quality; triclosan; endocrine disruptor (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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