Screening for Structural Hemoglobin Variants in Bahia, Brazil

Wellington Santos Silva, Roberto Ferreira De Oliveira, Sanzia Bezerra Ribeiro, Isabel Batista Da Silva, Edna Maria De Araújo and Abrahão Fontes Baptista
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Wellington Santos Silva: Bahia Adventist College, 44300-000 Cachoeira, Bahia, Brazil
Roberto Ferreira De Oliveira: Bahia Adventist College, 44300-000 Cachoeira, Bahia, Brazil
Sanzia Bezerra Ribeiro: Bahia Adventist College, 44300-000 Cachoeira, Bahia, Brazil
Isabel Batista Da Silva: Bahia Adventist College, 44300-000 Cachoeira, Bahia, Brazil
Edna Maria De Araújo: Feira de Santana State University, Health Department, 44031-460 Feira de Santana, Bahia, Brazil
Abrahão Fontes Baptista: Functional Electrostimulation Laboratory, Biomorphology Department, Health Sciences Instituto, Federal University of Bahia, Av. Reitor Miguel Calmon, s/n Vale do Canela, 40110-902 Salvador, Bahia, Brazil

IJERPH, 2016, vol. 13, issue 2, 1-6

Abstract: Brazil was the country that received the largest number of Africans during the time of colonization, and Bahia was the Brazilian state that received the largest number of slaves from Africa. The purpose of this study was to evaluate the coverage of the newborn screening program for sickle cell disease in the Recôncavo Baiano region of the state of Bahia, and to show the frequency of the subjects with hemoglobin variants in the 2006–2009 period. Blood samples from neonates in twelve cities in the Recôncavo Baiano region were analyzed by High Performance Liquid Chromatography. A total of 16,402 children were born in this period, 14,773 of which underwent newborn screening. In this period 1416 children were born carrying hemoglobin variants HbS and HbC. Forty-seven patients—20 HbSS genotype and 27 HbSC genotype—were diagnosed in eleven of the twelve cities surveyed. The proportion of children born with sickle cell disease in the Recôncavo Baiano region was 1/314, which was higher than the 1/650 rate for the state of Bahia. The data presented in this study confirm the high frequency of sickle cell disease in Recôncavo Baiano, demonstrating the need to create a referral center for the care of patients with sickle cell diseases in the region.

Keywords: hemoglobin variants; sickle cell disease; newborn screening (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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