Appropriate LDL-C-to-HDL-C Ratio Cutoffs for Categorization of Cardiovascular Disease Risk Factors among Uygur Adults in Xinjiang, China

Qing-Jie Chen, Hong-Mei Lai, Bang-Dang Chen, Xiao-Mei Li, Hui Zhai, Chun-Hui He, Shuo Pan, Jun-Yi Luo, Jing Gao, Fen Liu, Yi-Tong Ma and Yi-Ning Yang
Additional contact information
Qing-Jie Chen: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Hong-Mei Lai: Department of Cardiology, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China
Bang-Dang Chen: Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China
Xiao-Mei Li: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Hui Zhai: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Chun-Hui He: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Shuo Pan: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Jun-Yi Luo: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Jing Gao: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Fen Liu: Xinjiang Key Laboratory of Cardiovascular Disease Research, Urumqi 830054, China
Yi-Tong Ma: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China
Yi-Ning Yang: Department of Cardiology, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830054, China

IJERPH, 2016, vol. 13, issue 2, 1-12

Abstract: Elevated LDL-C/HDL-C ratio has been shown to be a marker of lipid metabolism as well as a good predictor of coronary artery disease (CAD). Thus, the aim of this study was to investigate whether the LDL-C/HDL-C ratio is useful for detecting cardiovascular disease (CVD) risk factors in general healthy Uygur adults in Xinjiang. A total of 4047 Uygur subjects aged ?35 years were selected from the Cardiovascular Risk Survey (CRS) study which was carried out from October 2007 to March 2010. Anthropometric data, blood pressure, lipid profile and fasting glucose were measured in all participants. The prevalence, sensitivity, specificity and distance on the receiver operating characteristic (ROC) curve of each LDL-C/HDL-C ratio were calculated. The prevalence of high LDL-C and low HDL-C cholesterol was high and positively correlated with higher LDL-C/HDL-C ratio in the Uygur population. In both men and women, we detected a slight apparent trend of high prevalence of hypertension and hypercholesterolemia with higher LDL-C/HDL-C ratio. Our study also demonstrated that the discriminatory power of the LDL-C/HDL-C ratio for CVD risk factors was slightly stronger in men than in women. Analysis of the shortest distance in the ROC curves for hypertension, dyslipidemia, diabetes, or ?two of these risk factors suggested a LDL-C/HDL-C ratio cutoff of 2.5 for both men and women. The results of this study showed that a LDL-C/HDL-C ratio cut-off of 2.5 might be used as the predictive marker to detect CVD risk factors among Uygur adults in Xinjiang.

Keywords: cutoff; LDL-C-to-HDL-C ratio; cardiovascular disease risk factors; Uygur adults; Xinjiang (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/13/2/235/pdf (application/pdf)
https://www.mdpi.com/1660-4601/13/2/235/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:13:y:2016:i:2:p:235-:d:64122

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().