Polymorphisms in Four Genes ( KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China

Kaiping Gao, Jinjin Wang, Linlin Li, Yujia Zhai, Yongcheng Ren, Haifei You, Bingyuan Wang, Xuli Wu, Jianna Li, Zichen Liu, Xiong Li, Yaxin Huang, Xin-Ping Luo, Dongsheng Hu, Kinji Ohno and Chongjian Wang
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Kaiping Gao: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China
Jinjin Wang: Department of Traditional Chinese Medicine Prevention, Preventive Medicine Research Evaluation Center, Henan University of Traditional Chinese Medicine, Zhengzhou 450001, China
Linlin Li: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Yujia Zhai: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Yongcheng Ren: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Haifei You: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Bingyuan Wang: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China
Xuli Wu: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China
Jianna Li: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China
Zichen Liu: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China
Xiong Li: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China
Yaxin Huang: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China
Xin-Ping Luo: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China
Dongsheng Hu: Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China
Kinji Ohno: Division of Neurogenetics, Center for Neurological Diseases and Cancer, University Graduate School of Medicine, Nagoya 4668550, Japan
Chongjian Wang: Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China

IJERPH, 2016, vol. 13, issue 3, 1-13

Abstract: Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations. The aim of the present study was to investigate the association of these four SNPs with T2DM in a large population of Han Chinese at Henan province, China. Seven-hundred-thirty-six patients with T2DM (cases) and Seven-hundred-sixty-eight healthy glucose-tolerant controls were genotyped for KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963. The association of genetic variants in these four genes with T2DM was analyzed using multivariate logistic regression. Genotypes and allele distributions of KCNQ1 rs151290 were significantly different between the cases and controls ( p < 0.05). The AC and CC genotypes and the combined AC + CC genotype of rs151290 in KCNQ1 were associated with increases risk of T2DM before (OR = 1.482, 95% CI = 1.062–2.069; p = 0.021; OR = 1.544, 95% CI = 1.097–2.172, p = 0.013; and OR = 1.509, 95% CI = 1.097–2.077, p = 0.011, respectively) and after (OR = 1.539, 95% CI = 1.015–2.332, p = 0.042; OR = 1.641, 95% CI = 1.070–2.516, p = 0.023; and OR = 1.582, 95% CI = 1.061–2.358, p = 0.024; respectively) adjustment for sex, age, anthropometric measurements, biochemical indexes, smoking and alcohol consumption. Consistent with results of genotype analysis, the C allele of rs151290 in KCNQ1 was also associated with increased risk of T2DM (OR = 1.166, 95% CI = 1.004–1.355, p = 0.045). No associations between genetic variants of KLF14 rs972283, GCKR rs780094 or MTNR1B rs10830963 and T2DM were detected. The AC and CC genotypes and the C allele of rs151290 in KCNQ1 may be risk factors for T2DM in Han Chinese in Henan province.

Keywords: single nucleotide polymorphism; KCNQ1; type 2 diabetes; risk factors (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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