Toxicity of Smokeless Tobacco Extract after 184-Day Repeated Oral Administration in Rats

Chenlin Yu, Ziteng Zhang, Yangang Liu, Ying Zong, Yongchun Chen, Xiuming Du, Jikuai Chen, Shijie Feng, Jinlian Hu, Shufang Cui and Guocai Lu
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Chenlin Yu: Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
Ziteng Zhang: Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
Yangang Liu: Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
Ying Zong: Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
Yongchun Chen: Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
Xiuming Du: Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
Jikuai Chen: Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
Shijie Feng: Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
Jinlian Hu: Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China
Shufang Cui: Laboratory Animal Centre, Second Military Medical University, Shanghai 200433, China
Guocai Lu: Department of Health Toxicology, College of Tropical Medicine and Public Health, Second Military Medical University, Shanghai 200433, China

IJERPH, 2016, vol. 13, issue 3, 1-16

Abstract: The use of smokeless tobacco (ST) is growing rapidly and globally. The consumption of ST is associated with an increased risk for developing chronic diseases, such as diabetes, hypercholesterolemia, and myocardial infarction, and has led to many public health problems. It is very important to access the toxicity of ST. This experiment presents data from 184-day toxicology studies in Sprague-Dawley (SD) rats designed to characterize the chronic effects of a smokeless tobacco extract (STE). The control group and treatment groups were matched for a range of nicotine levels. Animals were given STE by oral gavage with doses of 3.75 (low-dose), 7.50 (mid-dose) and 15.00 (high-dose) mg·nicotine/kg body weight/day for 184 days, followed by 30 days for recovery. Variables evaluated included body weights, feed consumption, clinical observations, clinical and anatomic pathology (including organ weights), and histopathology. Decreased body weights and organ weights (heart, liver and kidney) were found in animals in the mid-dose and high-dose groups. STE also showed moderate and reversible toxicity in esophagus, stomach, liver, kidney and lung.

Keywords: smokeless tobacco extract; toxicology; nicotine (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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