Antiviral Activity of Graphene–Silver Nanocomposites against Non-Enveloped and Enveloped Viruses

Yi-Ning Chen, Yi-Huang Hsueh, Chien-Te Hsieh, Dong-Ying Tzou and Pai-Ling Chang
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Yi-Ning Chen: Department of Bioscience Technology, Chung Yuan Christian University, 200 Chung Pei Road, Chung Li District, Taoyuan City 32023, Taiwan
Yi-Huang Hsueh: Graduate School of Biotechnology and Bioengineering, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan
Chien-Te Hsieh: Department of Chemical Engineering and Materials Science, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan
Dong-Ying Tzou: Department of Chemical Engineering and Materials Science, Yuan Ze University, 135 Yuan-Tung Road, Chung Li District, Taoyuan City 32003, Taiwan
Pai-Ling Chang: Division of General Pathology, Taoyuan General Hospital, Ministry of Health and Welfare, 1492 Zhongshan Road, Taoyuan City 33004, Taiwan

IJERPH, 2016, vol. 13, issue 4, 1-12

Abstract: The discovery of novel antiviral materials is important because many infectious diseases are caused by viruses. Silver nanoparticles have demonstrated strong antiviral activity, and graphene is a potential antimicrobial material due to its large surface area, high carrier mobility, and biocompatibility. No studies on the antiviral activity of nanomaterials on non-enveloped viruses have been reported. To investigate the antiviral activity of graphene oxide (GO) sheets and GO sheets with silver particles (GO-Ag) against enveloped and non-enveloped viruses, feline coronavirus (FCoV) with an envelope and infectious bursal disease virus (IBDV) without an envelope were chosen. The morphology and sizes of GO and GO-Ag were characterized by transmission, scanning electron microscopy, and X-ray diffraction. A virus inhibition assay was used to identify the antiviral activity of GO and GO-Ag. Go-Ag inhibited 25% of infection by FCoV and 23% by IBDV, whereas GO only inhibited 16% of infection by FCoV but showed no antiviral activity against the infection by IBDV. Further application of GO and GO-Ag can be considered for personal protection equipment to decrease the transmission of viruses.

Keywords: graphene oxide; silver nanoparticle; feline coronavirus; infectious bursal disease virus; enveloped virus; non-enveloped virus (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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