H-Type Hypertension and C Reactive Protein in Recurrence of Ischemic Stroke

Qing Zhang, Qiu De-Xing, Rong-Li Fu, Tian-Fen Xu, Meng-Juan Jing, Hui-Shan Zhang, He-Hong Geng, Long-Chao Zheng and Pei-Xi Wang
Additional contact information
Qing Zhang: Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China
Qiu De-Xing: Guangming New District People’s Hospital & Community Health Service Management Center of Guangming Area, Shenzhen 518000, China
Rong-Li Fu: Internal Medicine-Neurology, Huaihe Hospital, Henan University, Kaifeng 475000, China
Tian-Fen Xu: Basical School, Guangzhou Medical University, Guangzhou 510180, China
Meng-Juan Jing: Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China
Hui-Shan Zhang: Department of Preventive Medicine, School of Public Health, Guangzhou Medical University, Guangzhou 510180, China
He-Hong Geng: Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China
Long-Chao Zheng: Department of Public Health, School of Public Health, Graduate School of Guizhou Medical University, Guiyang 550025, China
Pei-Xi Wang: Institute of Public Health, School of Nursing, Henan University, Kaifeng 475004, China

IJERPH, 2016, vol. 13, issue 5, 1-9

Abstract: Hypertension with high homocysteine (HHcy) (H-type hypertension) and C reactive protein (CRP) can increase the incidence of ischemic stroke. However, it is not clear whether recurrent ischemic stroke (RIS) is related to H-type hypertension and CRP. The present study investigated the correlation of H-type hypertension and CRP level with RIS. Totally, 987 consecutive patients with acute ischemic stroke were recruited in a teaching hospital in Henan province, China during March 2014 to March 2015. The demographic and clinical characteristics and blood biochemical parameters of patients were analyzed. Elevated levels of CRP and homocysteine (Hcy) were defined as >8.2 mg/L and 10 ?mol/L, respectively. Among the 987 patients, 234 were RIS. Thirty-eight percent of RIS patients had elevated CRP level and 91.5% of RIS patients had HHcy. In multivariate analysis, adjusted odds ratio (OR) of RIS in patients aged ?60 years was 1.576 (95% CI: 1.125–2.207), in male patients 1.935 (95% CI: 1.385–2.704), in patients with diabetes 1.463 (95% CI: 1.037–2.064), CRP levels 1.013 (95% CI: 1.006–1.019), simple hypertension 3.370 (95% CI: 1.15–10.183), and H-type hypertension 2.990 (95% CI: 1.176–7.600). RIS was associated with older age, male, diabetes, H-type hypertension and CRP. Controlling H-type hypertension and CRP level may reduce the risk of RIS.

Keywords: C reactive protein; H-type hypertension; recurrence ischemic stroke (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations: View citations in EconPapers (1)

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