Brazilian Green Propolis Improves Antioxidant Function in Patients with Type 2 Diabetes Mellitus

Liting Zhao, Lingling Pu, Jingyu Wei, Jinghua Li, Jianquan Wu, Zhonghao Xin, Weina Gao and Changjiang Guo
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Liting Zhao: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China
Lingling Pu: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China
Jingyu Wei: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China
Jinghua Li: Department of Endocrinology, Pingjin Hospital, Tianjin 300162, China
Jianquan Wu: Department of Health Education, Tianjin Institute of Health Education, Tianjin 300011, China
Zhonghao Xin: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China
Weina Gao: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China
Changjiang Guo: Department of Nutrition, Tianjin Institute of Health and Environmental Medicine, Tianjin 300050, China

IJERPH, 2016, vol. 13, issue 5, 1-9

Abstract: Propolis contains a variety of bioactive components and possesses many biological properties. This study was designed to evaluate potential effects of Brazilian green propolis on glucose metabolism and antioxidant function in patients with type 2 diabetes mellitus (T2DM). In the 18-week randomized controlled study, enrolled patients with T2DM were randomly assigned to Brazilian green propolis group (900 mg/day) ( n = 32) and control group ( n = 33). At the end of the study, no significant difference was found in serum glucose, glycosylated hemoglobin, insulin, aldose reductase or adiponectin between the two groups. However, serum GSH and total polyphenols were significantly increased, and serum carbonyls and lactate dehydrogenase activity were significantly reduced in the Brazilian green propolis group. Serum TNF-? was significantly decreased, whereas serum IL-1? and IL-6 were significantly increased in the Brazilian green propolis group. It is concluded that Brazilian green propolis is effective in improving antioxidant function in T2DM patients.

Keywords: Brazilian green propolis; type 2 diabetes mellitus; antioxidant function (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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