Association of Children’s Urinary CC16 Levels with Arsenic Concentrations in Multiple Environmental Media

Paloma I. Beamer, Walter T. Klimecki, Miranda Loh, Yoshira Ornelas Van Horne, Anastasia J. Sugeng, Nathan Lothrop, Dean Billheimer, Stefano Guerra, Robert Clark Lantz, Robert A. Canales and Fernando D. Martinez
Additional contact information
Paloma I. Beamer: Asthma and Airways Disease Research Center, University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724, USA
Walter T. Klimecki: Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA
Miranda Loh: Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA
Yoshira Ornelas Van Horne: Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA
Anastasia J. Sugeng: Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA
Nathan Lothrop: Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA
Dean Billheimer: Asthma and Airways Disease Research Center, University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724, USA
Stefano Guerra: Asthma and Airways Disease Research Center, University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724, USA
Robert Clark Lantz: Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA
Robert A. Canales: Mel and Enid Zuckerman College of Public Health, University of Arizona, 1295 N. Martin Ave., Tucson, AZ 85724, USA
Fernando D. Martinez: Asthma and Airways Disease Research Center, University of Arizona, 1501 N. Campbell Ave., Tucson, AZ 85724, USA

IJERPH, 2016, vol. 13, issue 5, 1-16

Abstract: Arsenic exposure has been associated with decreased club cell secretory protein (CC16) levels in adults. Further, both arsenic exposure and decreased levels of CC16 in childhood have been associated with decreased adult lung function. Our objective was to determine if urinary CC16 levels in children are associated with arsenic concentrations in environmental media collected from their homes. Yard soil, house dust, and tap water were taken from 34 homes. Urine and toenail samples were collected from 68 children. All concentrations were natural log-transformed prior to data analysis. There were associations between urinary CC16 and arsenic concentration in soil ( b = ?0.43, p = 0.001, R 2 = 0.08), water ( b = ?0.22, p = 0.07, R 2 = 0.03), house dust ( b = ?0.37, p = 0.07, R 2 = 0.04), and dust loading ( b = ?0.21, p = 0.04, R 2 = 0.04). In multiple analyses, only the concentration of arsenic in soil was associated with urinary CC16 levels ( b = ?0.42, p = 0.02, R 2 = 0.14 (full model)) after accounting for other factors. The association between urinary CC16 and soil arsenic may suggest that localized arsenic exposure in the lungs could damage the airway epithelium and predispose children for diminished lung function. Future work to assess this possible mechanism should examine potential associations between airborne arsenic exposures, CC16 levels, lung function, and other possible confounders in children in arsenic-impacted communities.

Keywords: children; arsenic; respiratory health; CC16; uteroglobulin; multi-route exposure assessment; soil; drinking water (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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