BMI and BMD: The Potential Interplay between Obesity and Bone Fragility

Andrea Palermo, Dario Tuccinardi, Giuseppe Defeudis, Mikiko Watanabe, Luca D’Onofrio, Angelo Lauria Pantano, Nicola Napoli, Paolo Pozzilli and Silvia Manfrini
Additional contact information
Andrea Palermo: Department of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21, Rome 00128, Italy
Dario Tuccinardi: Department of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21, Rome 00128, Italy
Giuseppe Defeudis: Department of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21, Rome 00128, Italy
Mikiko Watanabe: Department of Experimental Medicine, Sapienza University of Rome, Rome 00185, Italy
Luca D’Onofrio: Department of Experimental Medicine, Polo Pontino, Sapienza University of Rome, Rome 00185, Italy
Angelo Lauria Pantano: Department of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21, Rome 00128, Italy
Nicola Napoli: Department of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21, Rome 00128, Italy
Paolo Pozzilli: Department of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21, Rome 00128, Italy
Silvia Manfrini: Department of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21, Rome 00128, Italy

IJERPH, 2016, vol. 13, issue 6, 1-30

Abstract: Recent evidence demonstrating an increased fracture risk among obese individuals suggests that adipose tissue may negatively impact bone health, challenging the traditional paradigm of fat mass playing a protective role towards bone health. White adipose tissue, far from being a mere energy depot, is a dynamic tissue actively implicated in metabolic reactions, and in fact secretes several hormones called adipokines and inflammatory factors that may in turn promote bone resorption. More specifically, Visceral Adipose Tissue (VAT) may potentially prove detrimental. It is widely acknowledged that obesity is positively associated to many chronic disorders such as metabolic syndrome, dyslipidemia and type 2 diabetes, conditions that could themselves affect bone health. Although aging is largely known to decrease bone strength, little is yet known on the mechanisms via which obesity and its comorbidities may contribute to such damage. Given the exponentially growing obesity rate in recent years and the increased life expectancy of western countries it appears of utmost importance to timely focus on this topic.

Keywords: osteoporosis; obesity; inflammation; fracture; body composition (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (4)

Downloads: (external link)
https://www.mdpi.com/1660-4601/13/6/544/pdf (application/pdf)
https://www.mdpi.com/1660-4601/13/6/544/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:13:y:2016:i:6:p:544-:d:71042

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().