Comparison of Individual and Combined Effects of Four Endocrine Disruptors on Estrogen Receptor Beta Transcription in Cerebellar Cell Culture: The Modulatory Role of Estradiol and Triiodo-Thyronine

Gergely Jocsak, David Sandor Kiss, Istvan Toth, Greta Goszleth, Tibor Bartha, Laszlo V. Frenyo, Tamas L. Horvath and Attila Zsarnovszky
Additional contact information
Gergely Jocsak: Department of Physiology and Biochemistry, Szent Istvan Faculty University of Veterinary Sciences, Budapest 1078, Hungary
David Sandor Kiss: Department of Physiology and Biochemistry, Szent Istvan Faculty University of Veterinary Sciences, Budapest 1078, Hungary
Istvan Toth: Department of Physiology and Biochemistry, Szent Istvan Faculty University of Veterinary Sciences, Budapest 1078, Hungary
Greta Goszleth: Department of Physiology and Biochemistry, Szent Istvan Faculty University of Veterinary Sciences, Budapest 1078, Hungary
Tibor Bartha: Department of Physiology and Biochemistry, Szent Istvan Faculty University of Veterinary Sciences, Budapest 1078, Hungary
Laszlo V. Frenyo: Department of Physiology and Biochemistry, Szent Istvan Faculty University of Veterinary Sciences, Budapest 1078, Hungary
Tamas L. Horvath: Section of Comparative Medicine, Yale University School of Medicine, New Haven, CT 06520, USA
Attila Zsarnovszky: Department of Physiology and Biochemistry, Szent Istvan Faculty University of Veterinary Sciences, Budapest 1078, Hungary

IJERPH, 2016, vol. 13, issue 6, 1-14

Abstract: Background : Humans and animals are continuously exposed to a number of environmental substances that act as endocrine disruptors (EDs). While a growing body of evidence is available to prove their adverse health effects, very little is known about the consequences of simultaneous exposure to a combination of such chemicals; Methods : Here, we used an in vitro model to demonstrate how exposure to bisphenol A, zearalenone, arsenic, and 4-methylbenzylidene camphor, alone or in combination, affect estrogen receptor ? (ER?) mRNA expression in primary cerebellar cell cultures. Additionally, we also show the modulatory role of intrinsic biological factors, such as estradiol (E2), triiodo-thyronine (T3), and glial cells, as potential effect modulators; Results : Results show a wide diversity in ED effects on ER? mRNA expression, and that the magnitude of these ED effects highly depends on the presence or absence of E2, T3, and glial cells; Conclusion : The observed potency of the EDs to influence ER? mRNA expression, and the modulatory role of E2, T3, and the glia suggests that environmental ED effects may be masked as long as the hormonal milieu is physiological, but may tend to turn additive or superadditive in case of hormone deficiency.

Keywords: estrogen receptor beta; transcription; bisphenol A; zearalenone; arsenic; camphor; combined treatment (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/13/6/619/pdf (application/pdf)
https://www.mdpi.com/1660-4601/13/6/619/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:13:y:2016:i:6:p:619-:d:72504

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().