Coarse Fraction Particle Matter and Exhaled Nitric Oxide in Non-Asthmatic Children

Hanne Krage Carlsen, Peter Boman, Bodil Björ, Anna-Carin Olin and Bertil Forsberg
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Hanne Krage Carlsen: Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, University of Umeå, Umeå 90187, Sweden
Peter Boman: Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, University of Umeå, Umeå 90187, Sweden
Bodil Björ: Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, University of Umeå, Umeå 90187, Sweden
Anna-Carin Olin: Section of Occupational and Environmental Medicine, Department of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy at University of Gothenburg, Gothenburg 40530, Sweden
Bertil Forsberg: Department of Public Health and Clinical Medicine, Occupational and Environmental Medicine, University of Umeå, Umeå 90187, Sweden

IJERPH, 2016, vol. 13, issue 6, 1-11

Abstract: Coarse particle matter, PM coarse , is associated with increased respiratory morbidity and mortality. The aim of this study was to investigate the association between short-term changes in PM coarse and sub-clininal airway inflammation in children. Healthy children aged 11 years from two northern Swedish elementary schools underwent fraction of exhaled nitrogen oxide (FENO) measurements to determine levels of airway inflammation twice weekly during the study period from 11 April–6 June 2011. Daily exposure to PM coarse , PM 2.5 , NO 2 , NOx, NO and O 3 and birch pollen was estimated. Multiple linear regression was used. Personal covariates were included as fixed effects and subjects were included as a random effect. In total, 95 children participated in the study, and in all 493 FENO measurements were made. The mean level of PM coarse was 16.1 ?g/m 3 (range 4.1–42.3), and that of O 3 was 75.0 ?g/m 3 (range: 51.3–106.3). That of NO 2 was 17.0 ?g/m 3 (range: 4.7–31.3), NOx was 82.1 ?g/m 3 (range: 13.3–165.3), and NO was 65 ?g/m 3 (range: 8.7–138.4) during the study period. In multi-pollutant models an interquartile range increase in 24 h PM coarse was associated with increases in FENO by between 6.9 ppb (95% confidence interval 0.0–14) and 7.3 ppb (95% confidence interval 0.4–14.9). PM coarse was associated with an increase in FENO, indicating sub-clinical airway inflammation in healthy children.

Keywords: exhaled NO; respiratory inflammation; coarse particle matter; air pollution; children (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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