2,4,6-Tribromophenol Interferes with the Thyroid Hormone System by Regulating Thyroid Hormones and the Responsible Genes in Mice

Dongoh Lee, Changhwan Ahn, Eui-Ju Hong, Beum-Soo An, Sang-Hwan Hyun, Kyung-Chul Choi and Eui-Bae Jeung
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Dongoh Lee: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Korea
Changhwan Ahn: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Korea
Eui-Ju Hong: Laboratory of Veterinary Biochemistry, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea
Beum-Soo An: Laboratory of Biochemistry, Department of Biomaterial Science, College of Natural Resources and Life Science, Pusan National University, Miryang, Kyeongnam 50463, Korea
Sang-Hwan Hyun: Laboratory of Veterinary Biotechnology and Embryology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Korea
Kyung-Chul Choi: Laboratory of Biochemistry and Immunology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Korea
Eui-Bae Jeung: Laboratory of Veterinary Biochemistry and Molecular Biology, College of Veterinary Medicine, Chungbuk National University, Cheongju, Chungbuk 362-763, Korea

IJERPH, 2016, vol. 13, issue 7, 1-11

Abstract: 2,4,6-Tribromophenol (TBP) is a brominated flame retardant (BFR). Based on its affinity for transthyretin, TBP could compete with endogenous thyroid hormone. In this study, the effects of TBP on the thyroid hormone system were assessed in mice. Briefly, animals were exposed to 40 and 250 mg/kg TBP. Thyroid hormones were also administered with or without TBP. When mice were treated with TBP, deiodinase 1 ( Dio1 ) and thyroid hormone receptor ? isoform 2 ( Thr?2 ) decreased in the pituitary gland. The levels of deiodinase 2 ( Dio2 ) and growth hormone ( Gh ) mRNA increased in response to 250 mg/kg of TBP, and the relative mRNA level of thyroid stimulating hormone ? ( Tsh? ) increased in the pituitary gland. Dio1 and Thr?1 expression in the liver were not altered, while Dio1 decreased in response to co-treatment with thyroid hormones. The thyroid gland activity decreased in response to TBP, as did the levels of free triiodothyronine and free thyroxine in serum. Taken together, these findings indicate that TBP can disrupt thyroid hormone homeostasis and the presence of TBP influenced thyroid actions as regulators of gene expression. These data suggest that TBP interferes with thyroid hormone systems

Keywords: endocrine disruptor; 2,4,6-tribromophenol; thyroid hormone (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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