Potential Harmful Effects of PM 2.5 on Occurrence and Progression of Acute Coronary Syndrome: Epidemiology, Mechanisms, and Prevention Measures

Xu Meng, Ying Zhang, Kun-Qi Yang, Yan-Kun Yang and Xian-Liang Zhou
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Xu Meng: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Beijing 100037, China
Ying Zhang: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Beijing 100037, China
Kun-Qi Yang: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Beijing 100037, China
Yan-Kun Yang: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Beijing 100037, China
Xian-Liang Zhou: Department of Cardiology, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 167, Beilishi Road, Beijing 100037, China

IJERPH, 2016, vol. 13, issue 8, 1-16

Abstract: The harmful effects of particulate matter with an aerodynamic diameter of <2.5 µm (PM 2.5 ) and its association with acute coronary syndrome (ACS) has gained increased attention in recent years. Significant associations between PM 2.5 and ACS have been found in most studies, although sometimes only observed in specific subgroups. PM 2.5 -induced detrimental effects and ACS arise through multiple mechanisms, including endothelial injury, an enhanced inflammatory response, oxidative stress, autonomic dysfunction, and mitochondria damage as well as genotoxic effects. These effects can lead to a series of physiopathological changes including coronary artery atherosclerosis, hypertension, an imbalance between energy supply and demand to heart tissue, and a systemic hypercoagulable state. Effective strategies to prevent the harmful effects of PM 2.5 include reducing pollution sources of PM 2.5 and population exposure to PM 2.5 , and governments and organizations publicizing the harmful effects of PM 2.5 and establishing air quality standards for PM 2.5 . PM 2.5 exposure is a significant risk factor for ACS, and effective strategies with which to prevent both susceptible and healthy populations from an increased risk for ACS have important clinical significance in the prevention and treatment of ACS.

Keywords: acute coronary syndrome; PM 2.5; epidemiology; mechanisms; prevention measures (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (4)

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