Severe and Moderate Asthma Exacerbations in Asthmatic Children and Exposure to Ambient Air Pollutants

Louis-Francois Tétreault, Marieve Doucet, Philippe Gamache, Michel Fournier, Allan Brand, Tom Kosatsky and Audrey Smargiassi
Additional contact information
Louis-Francois Tétreault: Department of Environmental and Occupational Health, School of Public Health, University of Montreal, Montréal, QC H2L 1M3, Canada
Marieve Doucet: Institut Natonal de la Santé Publique du Québec, Québec, QC H2L 1M3, Canada
Philippe Gamache: Institut Natonal de la Santé Publique du Québec, Québec, QC H2L 1M3, Canada
Michel Fournier: Direction Régionale de Santé Publique du CIUSSS Centre-Sud-de-l’Île-de-Montréalde Montréal, Montréal, QC H2L 1M3, Canada
Allan Brand: Institut Natonal de la Santé Publique du Québec, Québec, QC H2L 1M3, Canada
Tom Kosatsky: British Columbia Centre for Disease Control, Vancouver, BC V5Z 4R4, Canada
Audrey Smargiassi: Department of Environmental and Occupational Health, School of Public Health, University of Montreal, Montréal, QC H2L 1M3, Canada

IJERPH, 2016, vol. 13, issue 8, 1-12

Abstract: Background: It is well established that short-term exposure to ambient air pollutants can exacerbate asthma, the role of early life or long-term exposure is less clear. We assessed the association between severe asthma exacerbations with both birth and annual exposure to outdoor air pollutants with a population-based cohort of asthmatic children in the province of Quebec (Canada). Method: Exacerbations of asthma occurring between 1 April 1996 and 31 March 2011 were defined as one hospitalization or emergency room visit with a diagnosis of asthma for children (<13 years old) already diagnosed with asthma. Annual daily average concentrations of ozone (O 3 ) and nitrogen dioxide (NO 2 ) were estimated at the child’s residential postal code. Satellite based levels of fine particulate (PM 2.5 ) estimated for a grid of 10 km by 10 km were also assigned to postal codes of residence for the whole province. Hazard ratios (HRs) were estimated from Cox models with a gap time approach for both birth and time-dependant exposure. Results: Of the 162,752 asthmatic children followed (1,020,280 person-years), 35,229 had at least one asthma exacerbation. The HRs stratified by age groups and adjusted for the year of birth, the ordinal number of exacerbations, sex, as well as material and social deprivation, showed an interquartile range increase in the time-dependant exposure to NO 2 (4.95 ppb), O 3 (3.85 ppb), and PM 2.5 (1.82 ?g/m 3 ) of 1.095 (95% CI 1.058–1.131), 1.052 (95% CI 1.037–1.066) and 1.025 (95% CI 1.017–1.031), respectively. While a positive association was found to PM 2.5 , no associations were found between exposure at birth to NO 2 or O 3 . Conclusions: Our results support the conclusion, within the limitation of this study, that asthma exacerbations in asthmatic children are mainly associated with time dependent residential exposures less with exposure at birth.

Keywords: asthma; air pollution; childhood; exacerbation (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View references in EconPapers View complete reference list from CitEc
Citations: View citations in EconPapers (3)

Downloads: (external link)
https://www.mdpi.com/1660-4601/13/8/771/pdf (application/pdf)
https://www.mdpi.com/1660-4601/13/8/771/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:13:y:2016:i:8:p:771-:d:75131

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().