Association between Exposure to Endocrine Disruptors in Drinking Water and Preterm Birth, Taking Neighborhood Deprivation into Account: A Historic Cohort Study

Marion Albouy-Llaty, Frédérike Limousi, Camille Carles, Antoine Dupuis, Sylvie Rabouan and Virginie Migeot
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Marion Albouy-Llaty: Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France
Frédérike Limousi: Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France
Camille Carles: Epidemiology of Cancer and Environmental Exposures, Inserm U1219, University of Bordeaux, 146 rue Léo Saignat, 33076 Bordeaux, France
Antoine Dupuis: Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France
Sylvie Rabouan: Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France
Virginie Migeot: Department of Analytical Chemistry, Pharmaceutics and Epidemiology, School of Medicine and Pharmacy, University of Poitiers, 6 rue de la Milétrie, 86034 Poitiers Cedex, France

IJERPH, 2016, vol. 13, issue 8, 1-16

Abstract: Background : The relationship between preterm birth (PTB) and endocrine disruptor exposure in drinking-water has only occasionally been studied. The objective of this work was to investigate the relation between exposure to atrazine metabolites, or atrazine/nitrate mixtures, in drinking-water during pregnancy and prevalence of PTB neonates, while taking neighborhood deprivation into account. Method : A historic cohort study in Deux-Sèvres, France, between 2005 and 2010 with a multiple imputation model for data of exposure to atrazine metabolites and a logistic regression were carried out. Results : We included 13,654 mother/neonate pairs living in 279 different census districts. The prevalence of PTB was 4%. Average atrazine metabolite concentration was 0.019 ± 0.009 (0.014–0.080) µg/L and 39% of mothers lived in less deprived areas. The individual data were associated with risk of PTB. The risk of PTB when exposed to highest concentration of atrazine metabolite adjusted for confounders, was ORa 1.625 95% CI [0.975; 2.710]. Taking, or not, neighborhood deprivation into account did not change the result. Exposure to atrazine/nitrate mixtures remained non-significant. Conclusions : Even if we took neighborhood deprivation into account, we could not show a significant relationship between exposure to atrazine metabolites, or mixtures, in drinking-water during the second trimester of pregnancy and PTB.

Keywords: endocrine disruptor; mixture; drinking-water; preterm birth; social inequalities; European deprivation index (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations: View citations in EconPapers (2)

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Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:13:y:2016:i:8:p:796-:d:75662

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