Associations of Cough Prevalence with Ambient Polycyclic Aromatic Hydrocarbons, Nitrogen and Sulphur Dioxide: A Longitudinal Study

Enoch Olando Anyenda, Tomomi Higashi, Yasuhiro Kambayashi, Thao Thi Thu Nguyen, Yoshimasa Michigami, Masaki Fujimura, Johsuke Hara, Hiromasa Tsujiguchi, Masami Kitaoka, Hiroki Asakura, Daisuke Hori, Yohei Yamada, Koichiro Hayashi, Kazuichi Hayakawa and Hiroyuki Nakamura
Additional contact information
Enoch Olando Anyenda: Department of Environmental and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Tomomi Higashi: Department of Hygiene, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Yasuhiro Kambayashi: Department of Environmental and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Thao Thi Thu Nguyen: Department of Environmental and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Yoshimasa Michigami: Environment Preservation Center, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
Masaki Fujimura: Respiratory Medicine, Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Johsuke Hara: Respiratory Medicine, Cellular Transplantation Biology, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Hiromasa Tsujiguchi: Department of Environmental and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Masami Kitaoka: Department of Environmental and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Hiroki Asakura: Department of Environmental and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Daisuke Hori: Department of Environmental and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Yohei Yamada: Department of Environmental and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Koichiro Hayashi: Department of Environmental and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
Kazuichi Hayakawa: Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Pharmacy, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa, Ishikawa 920-1192, Japan
Hiroyuki Nakamura: Department of Environmental and Preventive Medicine, Graduate School of Medical Sciences, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan

IJERPH, 2016, vol. 13, issue 8, 1-13

Abstract: Information on potential cough triggers including environmental irritants is vital for successful management of chronic cough in patients. We investigated the relationship between ambient levels of particulate polycyclic aromatic hydrocarbons (PAH), nitrogen dioxide (NO 2 ) and sulphur dioxide (SO 2 ) exposures with cough prevalence. Eighty-three adult patients, who had been physician diagnosed with at least asthma, cough variant asthma and/or atopic cough, were divided into asthma and non-asthma groups. They recorded daily cough symptoms during 4 January–30 June 2011 study period while daily samples of total suspended particles were simultaneously collected by use of glass fiber filters and the particulate PAH content determined by high performance liquid chromatography coupled with a fluorescence detector. Ambient concentrations of NO 2 and SO 2 were obtained from a local monitoring site. Logistic regression models using generalized estimating equations were used to determine population-averaged estimates of association between cough prevalence and ambient pollutant exposures for the two groups. Fully adjusted odds ratios from single pollutant models were 1.083 (95% confidence interval (CI): 1.029, 1.140) and 1.097 (95% CI: 1.016, 1.185) per 0.57 ng/m 3 for lag2 PAH exposure, while only for asthma group had significant associations with NO 2 and SO 2 exposures for both lag2 and lag02. Similar associations were observed in multipollutant models. This finding suggests that ambient PAH, NO 2 , and SO 2 exposure even at low levels is related to cough prevalence in adult chronic cough patients and may be considered as aggravating factor during clinical management of the condition.

Keywords: polycyclic aromatic hydrocarbon; adult patients; asthma; generalized estimating equation; total suspended particles; chronic cough (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
References: View complete reference list from CitEc
Citations:

Downloads: (external link)
https://www.mdpi.com/1660-4601/13/8/800/pdf (application/pdf)
https://www.mdpi.com/1660-4601/13/8/800/ (text/html)

Related works:
This item may be available elsewhere in EconPapers: Search for items with the same title.

Export reference: BibTeX RIS (EndNote, ProCite, RefMan) HTML/Text

Persistent link: https://EconPapers.repec.org/RePEc:gam:jijerp:v:13:y:2016:i:8:p:800-:d:75604

Access Statistics for this article

IJERPH is currently edited by Ms. Jenna Liu

More articles in IJERPH from MDPI
Bibliographic data for series maintained by MDPI Indexing Manager ().