PHACTR1 Gene Polymorphism Is Associated with Increased Risk of Developing Premature Coronary Artery Disease in Mexican Population

Nonanzit Pérez-Hernández, Gilberto Vargas-Alarcón, Rosalinda Posadas-Sánchez, Nancy Martínez-Rodríguez, Carlos Alfonso Tovilla-Zárate, Adrián Asael Rodríguez-Cortés, Oscar Pérez-Méndez, Ruben Blachman-Braun and José Manuel Rodríguez-Pérez
Additional contact information
Nonanzit Pérez-Hernández: Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico
Gilberto Vargas-Alarcón: Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico
Rosalinda Posadas-Sánchez: Department of Endocrinology, National Institute of Cardiology “Ignacio Chávez”, Mexico City 14080, Mexico
Nancy Martínez-Rodríguez: Community Health Research Department, Children’s Hospital of Mexico “Federico Gomez”, Ministry of Health (SSA), Mexico City 06720, Mexico
Carlos Alfonso Tovilla-Zárate: Juarez Autonomous University of Tabasco, Multidisciplinary Academic Division of Comacalco, Villahermosa 86040, Mexico
Adrián Asael Rodríguez-Cortés: Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico
Oscar Pérez-Méndez: Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico
Ruben Blachman-Braun: Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico
José Manuel Rodríguez-Pérez: Department of Molecular Biology, National Institute of Cardiology “Ignacio Chávez”, Juan Badiano No. 1, Col. Sección XVI, Tlalpan 14080, Mexico City, Mexico

IJERPH, 2016, vol. 13, issue 8, 1-9

Abstract: Single-nucleotide polymorphisms (SNPs) in the protein phosphatase and actin regulator 1 gene ( PHACTR1 ) have been associated with susceptibility to develop several diseases, including cardiovascular disease. The purpose of this study was to evaluate the role of two polymorphisms (rs2026458 and rs9349379) of the PHACTR1 gene in the susceptibility to the risk of developing premature coronary artery disease (CAD) in the Mexican population. The genotype analysis was performed using 5’exonuclease TaqMan genotyping assays in a group of 994 patients with premature CAD and 703 controls. A similar genotype distribution of rs2026458 was observed in both groups; however, under an additive model adjusted by age, body mass index, type 2 diabetes mellitus, smoking, dyslipidemia, and hypertension, the rs9349379 G allele was associated with a higher risk for developing premature CAD (odds ratio (OR) = 1.22, 95% confidence interval (CI) = 1.03–1.46, p -value ( p ) = 0.024). The two PHACTR1 polymorphisms were not in linkage disequilibrium. In summary, our results suggest that the PHACTR1 rs9349379 polymorphism plays an important role in the risk of developing premature CAD in the Mexican population.

Keywords: coronary artery disease; genetic polymorphisms; vascular calcification; PHACTR1 gene (search for similar items in EconPapers)
JEL-codes: I I1 I3 Q Q5 (search for similar items in EconPapers)
Date: 2016
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